The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection.

中文翻译：

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基于表面增强拉曼光谱的快速无标记尿液检测，用于不同阶段结直肠癌的无创检测


能够在杯子里小便并筛查结直肠癌（CRC）的概念对广大公众来说很着迷。这里，采用基于表面增强拉曼光谱 (SERS) 的简单且无标记的尿液测试来进行 CRC 检测。观察到正常、I-II 期和 III-IV 期 CRC 尿液之间存在显着的光谱差异。使用判别函数分析，在训练模型中对正常、I-II 期和 III-IV 期 CRC 分类的诊断灵敏度达到 95.8%、80.9% 和 84.3%，这表明尿液 SERS 作为快速诊断方法的巨大前景。 ，方便、无创的CRC分期检测方法。