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Background-free fibre optic Brillouin probe for remote mapping of micromechanics
Biomedical Optics Express ( IF 3.4 ) Pub Date : 2020-10-26 , DOI: 10.1364/boe.404535
YuChen Xiang 1 , Carin Basirun 2 , Joshua Chou 2 , Majid E Warkiani 2 , Peter Török 1, 3 , Yingying Wang 4 , Shoufei Gao 4 , Irina V Kabakova 5
Affiliation  

Brillouin imaging (BI) has become a valuable tool for micromechanical material characterisation, thanks to extensive progress in instrumentation in the last few decades. This powerful technique is contactless and label-free, thus making it especially suitable for biomedical applications. Nonetheless, to fully harness the non-contact and non-destructive nature of BI, transformational changes in instrumentation are still needed to extend the technology’s utility into the domain of in vivo and in situ operation, which we foresee to be particularly crucial for wide spread usage of BI, e.g. in medical diagnostics and pathology screening. This work addresses this challenge by presenting the first demonstration of a fibre-optic Brillouin probe, capable of mapping the micromechanical properties of a tissue-mimicking phantom. This is achieved through combination of miniaturised optical design, advanced hollow-core fibre fabrication and high-resolution 3D printing. Our prototype probe is compact, background-free and possesses the highest collection efficiency to date, thus providing the foundation of a fibre-based Brillouin device for remote, in situ measurements in challenging and otherwise difficult-to-reach environments in biomedical, material science and industrial applications.

中文翻译:

用于微机械远程测绘的无背景光纤布里渊探头

由于过去几十年仪器仪表的巨大进步,布里渊成像 (BI) 已成为微机械材料表征的重要工具。这种强大的技术是非接触式和无标签的,因此特别适合生物医学应用。尽管如此,为了充分利用 BI 的非接触式和非破坏性特性,仍然需要对仪器进行变革,以将该技术的实用性扩展到体内原位操作领域,我们预计这对于广泛传播尤其重要BI 的使用,例如在医学诊断和病理学筛查中的应用。这项工作通过首次演示光纤布里渊探针来解决这一挑战,该探针能够绘制模拟组织模型的微机械特性。这是通过小型化光学设计、先进的空心光纤制造和高分辨率 3D 打印的结合来实现的。我们的原型探头结构紧凑,无背景,具有迄今为止最高的收集效率,从而为基于光纤的布里渊装置奠定了基础,用于在生物医学、材料科学领域具有挑战性和其他难以到达的环境中进行远程原位测量和工业应用。
更新日期:2020-11-15
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