Abstract

Context

The prevalence of diabetic neuropathy is drastically increasing in the world. To halt the progression of diabetic neuropathy, there is an unmet need to have potential biomarkers for the diagnosis and new drug discovery.

Objective

To study various biomarkers involved in the pathogenesis of diabetic neuropathy.

Methods

The literature was searched with the help of various scientific databases and resources like PubMed, ProQuest, Scopus, and Google scholar from the year 1976 to 2020.

Results

Biomarkers of diabetic neuropathy are categorised as inflammatory biomarkers such as MCP-1, VEGF, TRPV1, NF-κB; oxidative biomarkers such as adiponectin, NFE2L2; enzyme biomarkers like NADPH, ceruloplasmin, HO-1, DPP-4, PARP α; miscellaneous biomarkers such as SIRT1, caveolin 1, MALAT1, and microRNA. All biomarkers have a significant role in the pathogenesis of diabetic neuropathy.

Conclusion

These biomarkers have a potential role in the progression of diabetic neuropathy and can be considered as potential targets for new drug discovery.

中文翻译：

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糖尿病神经病变的生物标志物

摘要

语境

糖尿病性神经病变的患病率在世界范围内急剧增加。为了阻止糖尿病性神经病变的进展，对诊断和新药发现的潜在生物标志物的需求尚未得到满足。

客观的

研究参与糖尿病性神经病变发病机制的各种生物标志物。

方法

从 1976 年到 2020 年，在 PubMed、ProQuest、Scopus 和 Google 学者等各种科学数据库和资源的帮助下搜索了这些文献。

结果

糖尿病神经病变的生物标志物被归类为炎症生物标志物，如 MCP-1、VEGF、TRPV1、NF-κB；氧化生物标志物，如脂联素、NFE2L2；酶生物标志物，如 NADPH、血浆铜蓝蛋白、HO-1、DPP-4、PARP α；各种生物标志物，如 SIRT1、caveolin 1、MALAT1 和 microRNA。所有生物标志物在糖尿病性神经病变的发病机制中都具有重要作用。

结论

这些生物标志物在糖尿病性神经病变的进展中具有潜在作用，可被视为新药发现的潜在靶点。