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A Pd-Free Sonogashira Coupling Protocol Employing an In-situ-Prepared Copper/Chelating 1,2,3-Triazolylidene System
Synlett ( IF 1.7 ) Pub Date : 2020-10-15 , DOI: 10.1055/a-1290-8469
Biprajit Sarkar 1, 2 , Georgios C. Vougioukalakis 3 , Efstathios Tonis 3 , Felix Stein 1 , Ioannis K. Stamatopoulos 3 , Jessica Stubbe 1 , Athanasios Zarkadoulas 3
Affiliation  

A new, palladium-free Sonogashira coupling reaction protocol using a catalytic system that comprises a simple, cheap, widely available copper salt and a chelating 1,2,3-triazolylidene ligand precursor is reported. This protocol provides the desired coupling products in moderate to very good yields.

中文翻译:

采用原位制备的铜/螯合 1,2,3-三唑基系统的无 Pd Sonogashira 偶联方案

报道了一种新的无钯 Sonogashira 偶联反应方案,该方案使用催化系统,该系统包括简单、廉价、广泛可用的铜盐和螯合 1,2,3-三唑基配体前体。该协议以中等至非常好的产量提供所需的耦合产品。
更新日期:2020-10-15
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