Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity,European Journal of Immunology

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Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-11-14 , DOI: 10.1002/eji.201948402
Noëlla Lopes ₁ , Bruno Silva-Santos ₁

Affiliation

γδ T cells can display a plethora of immune functions, but recent studies have highlighted their importance, in multiple disease models, as sources of the pro‐inflammatory cytokines, IL‐17A (IL‐17), and IFN‐γ. These are produced by distinct murine effector γδ T cell subsets that diverge during thymic γδ T cell development. Among the multiple roles these subsets play in peripheral tissues, a striking dichotomy has emerged at tumor sites: whereas IFN‐γ⁺ γδ T cells inhibit tumor cell growth, IL‐17⁺ γδ T cells promote tumor progression and metastasis formation. In this review, we discuss the main lines of evidence, mostly from preclinical studies in mouse models, for this functional dichotomy in cancer immunity. We further highlight very recent advances in our understanding how metabolic sources and pathways can impact on the balance between IFN‐γ⁺ and IL‐17⁺ γδ T cells in the tumor microenvironment, which opens a new exciting avenue to explore toward the application of γδ T cells in cancer immunotherapy.

中文翻译：

小鼠γδ T细胞亚群在癌症免疫中的功能和代谢二分法

γδ T 细胞可以表现出多种免疫功能，但最近的研究强调了它们在多种疾病模型中的重要性，作为促炎细胞因子 IL-17A (IL-17) 和 IFN-γ 的来源。这些是由不同的鼠效应 γδ T 细胞亚群产生的，这些亚群在胸腺 γδ T 细胞发育过程中发生分化。这些亚群在外周组织中发挥多种作用，在肿瘤部位出现了惊人的二分法：IFN-γ ⁺ γδ T 细胞抑制肿瘤细胞生长，而 IL-17 ⁺ γδ T 细胞促进肿瘤进展和转移形成。在这篇综述中，我们讨论了癌症免疫中这种功能二分法的主要证据，主要来自小鼠模型的临床前研究。我们进一步强调了我们在理解代谢来源和途径如何影响肿瘤微环境中 IFN-γ ⁺和 IL-17 ⁺ γδ T 细胞之间的平衡方面的最新进展，这为探索 γδ 的应用开辟了一条新的令人兴奋的途径T 细胞在癌症免疫治疗中的应用。

更新日期：2021-01-12

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