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The attentive focus on T cell‐mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo
Scandinavian Journal of Immunology ( IF 4.1 ) Pub Date : 2020-11-15 , DOI: 10.1111/sji.13000
Azin Aghamajidi 1 , Ehsan Raoufi 2 , Gilda Parsamanesh 3 , Ahmad Jalili 4 , Mohammad Salehi‐Shadkami 5 , Marjan Mehrali 5 , Monireh Mohsenzadegan 6
Affiliation  

T cell‐mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune‐pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.

中文翻译:

专注于牛皮癣,扁平苔藓和白癜风的T细胞介导的自身免疫性发病机制

T细胞介导的自身免疫性皮肤病是由于对皮肤细胞的异常免疫反应而导致的,其中T细胞起着核心作用。这些慢性炎性皮肤疾病涵盖各种类型,包括牛皮癣,扁平苔藓和白癜风。这些疾病在免疫病理生理学上有相似之处。在过去的十年中,由于对病理生理学有了更好的了解,免疫调节剂在治疗这些疾病方面非常成功。在这篇综述中,我们将讨论免疫致病机制,并强调T淋巴细胞在牛皮癣,扁平苔藓和白癜风中的作用。这项研究可以为更好地了解靶向治疗途径和生物疗法提供新的见解。
更新日期:2020-11-15
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