Acquired tick resistance is a phenomenon wherein the host elicits an immune response against tick salivary components upon repeated tick infestations. The immune responses, potentially directed against critical salivary components, thwart tick feeding, and the animal becomes resistant to subsequent tick infestations. The development of tick resistance is frequently observed when ticks feed on non‐natural hosts, but not on natural hosts. The molecular mechanisms that lead to the development of tick resistance are not fully understood, and both host and tick factors are invoked in this phenomenon. Advances in molecular tools to address the host and the tick are beginning to reveal new insights into this phenomenon and to uncover a deeper understanding of the fundamental biology of tick‐host interactions. This review will focus on the expanding understanding of acquired tick resistance and highlight the impact of this understanding on anti‐tick vaccine development efforts.

中文翻译：

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获得性蜱抵抗力：小道很热

获得性蜱抗性是一种现象，其中宿主在重复蜱侵染时引发针对蜱唾液成分的免疫反应。可能针对关键唾液成分的免疫反应会阻止蜱虫进食，并且动物对随后的蜱虫感染产生抵抗力。当蜱以非天然宿主而不是天然宿主为食时，经常观察到蜱抗性的发展。导致蜱抗性发展的分子机制尚不完全清楚，在这种现象中，宿主和蜱因子都被调用。解决宿主和蜱的分子工具的进步开始揭示对这种现象的新见解，并揭示对蜱-宿主相互作用的基本生物学的更深入理解。