Intermediate filaments (IFs) perform a diverse set of well‐known functions including providing structural support for the cell and resistance to mechanical stress, yet recent evidence has revealed unexpected roles for IFs as stress response proteins. Previously, it was shown that the type III IF protein vimentin forms cage‐like structures around centrosome‐associated proteins destined for degradation, structures referred to as aggresomes, suggesting a role for vimentin in protein turnover. However, vimentin's function at the aggresome has remained largely understudied. In a recent report, vimentin was shown to be dispensable for aggresome formation, but played a critical role in protein turnover at the aggresome through localizing proteostasis‐related machineries, such as proteasomes, to the aggresome. Here, we review evidence for vimentin's function in proteostasis and highlight the organismal implications of these findings.

中文翻译：

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Vimentin 的副业：调节哺乳动物系统中的细胞蛋白质稳态

中间丝 (IFs) 具有多种众所周知的功能，包括为细胞提供结构支持和抵抗机械应力，但最近的证据表明，IFs 作为应激反应蛋白具有意想不到的作用。以前，研究表明，III 型 IF 蛋白波形蛋白在注定要降解的中心体相关蛋白周围形成笼状结构，这种结构称为聚集体，表明波形蛋白在蛋白质周转中起作用。然而，波形蛋白在聚集体中的功能在很大程度上仍未得到充分研究。在最近的一份报告中，波形蛋白被证明对于聚集体的形成是可有可无的，但通过将蛋白酶体等与蛋白稳态相关的机制定位到聚集体，在聚集体的蛋白质周转中发挥了关键作用。在这里，我们审查波形的证据