The SARS‐CoV‐2 pandemic has caused profound changes in nearly all routines associated with day‐to‐day life around the world. Governments and national institutions have put several regulatory guidelines in place to try and limit the spread of the virus in high‐footfall, multioccupancy environments such as offices, public transport hubs, hospitals, and care homes. These have included procedures around hand hygiene, cough/sneeze hygiene, maintaining physical distancing, and the use of personal protective equipment (PPE). Shared Resource Laboratories (SRLs) are by nature high‐footfall, multioccupancy environments where surfaces are touched and instruments interacted with by many different people and therefore present with the exact same challenges as other public enclosed spaces. Moreover, SRL staff often interact with several different people in normal day‐to‐day operation, often in close proximity. Therefore, it is highly possible that the actions of one person could have far reaching consequences for the health and well‐being of other users and SRL staff. An outbreak of COVID‐19 linked to an SRL would inevitably lead to serious reputational damage at both local and institutional levels. Closing down the SRL is simply not an effective solution as much of the technology and expertise housed within the facility will be essential for research into understanding the nature COVID‐19 and how we can combat it.

Many SRLs have rapidly adapted their operations to incorporate and adhere to regulatory guidelines driven by biosafety concerns, often imposed by governmental and institutional bodies. In this manuscript, we describe how these new regulatory guidelines can be applied to the SRL setting, and how they essentially fall into three broad categories: (1) regulation of access to the SRL space, instruments and services; (2) regulation and control of SRL space; and (3) regulation of SRL staff, user and external visitor (service engineers) behaviors within the SRL space (see Fig. 1). Ultimately, the need to adopt regulatory procedures will be driven by biosafety considerations directly related to the threat and control of SARS‐CoV‐2, as well as the resulting necessary modification to how the SRL operates. Both of these subjects will be covered in detail elsewhere (please see the biosafety and operations papers in this special edition).

The regulatory guidelines outlined herein are based upon common guidelines that have been adopted at the authors' institutions across distinct geographical areas (UK, North America, Central America, Australia). Where possible we have also highlighted specific Government guidelines. It is important to note that determining which measures or how strictly to adopt these measures will depend on your location and the recommendations of your local government/institutional policies. When instituting new COVID‐related policies in your SRL, ensure that you comply with any locally enacted guidelines and liaise with relevant safety officers. While most of these guidelines have been described for implementation within the flow cytometry SRL, they are also more broadly applicable to any SRL settings where the predominant operational model is based on multiuser access to space and instrumentation. Finally, in order to gain compliance in following the new regulatory guidelines, it is recommended that the rationale behind the guidelines be explained as new policies are enacted.

SARS-CoV-2 大流行已导致世界各地几乎所有与日常生活相关的日常生活发生了深刻的变化。政府和国家机构已经制定了几项监管指南，试图限制病毒在人流量大、多人入住的环境中传播，例如办公室、公共交通枢纽、医院和疗养院。这些措施包括手部卫生、咳嗽/打喷嚏卫生、保持身体距离和使用个人防护设备 (PPE) 的程序。共享资源实验室 (SRL) 本质上是人流量大、多人使用的环境，在该环境中，许多不同的人会接触到表面并与仪器进行交互，因此面临与其他公共封闭空间完全相同的挑战。而且，SRL 工作人员在正常的日常运营中经常与几个不同的人互动，而且通常很接近。因此，一个人的行为极有可能对其他用户和 SRL 工作人员的健康和福祉产生深远的影响。与 SRL 相关的 COVID-19 爆发将不可避免地在地方和机构层面造成严重的声誉损害。关闭 SRL 根本不是一个有效的解决方案，因为设施内的许多技术和专业知识对于了解 COVID-19 的性质以及我们如何对抗它的研究至关重要。与 SRL 相关的 COVID-19 爆发将不可避免地在地方和机构层面造成严重的声誉损害。关闭 SRL 根本不是一个有效的解决方案，因为设施内的许多技术和专业知识对于了解 COVID-19 的性质以及我们如何对抗它的研究至关重要。与 SRL 相关的 COVID-19 爆发将不可避免地在地方和机构层面造成严重的声誉损害。关闭 SRL 根本不是一个有效的解决方案，因为设施内的许多技术和专业知识对于了解 COVID-19 的性质以及我们如何对抗它的研究至关重要。

许多 SRL 已迅速调整其运营，以纳入并遵守由生物安全问题驱动的监管准则，这些准则通常由政府和机构机构实施。在本手稿中，我们描述了如何将这些新的监管指南应用于 SRL 环境，以及它们本质上如何分为三大类：（1）对 SRL 空间、工具和服务访问的监管；（2）SRL空间的调控；(3) SRL 空间内的 SRL 员工、用户和外部访问者（服务工程师）行为的监管（见图 1）。最终，与 SARS-CoV-2 的威胁和控制直接相关的生物安全考虑以及由此产生的对 SRL 运作方式的必要修改将推动采用监管程序的需要。

本文概述的监管指南基于作者机构在不同地理区域（英国、北美、中美洲、澳大利亚）采用的通用指南。在可能的情况下，我们还强调了具体的政府指导方针。请务必注意，确定采取哪些措施或采取这些措施的严格程度将取决于您所在的位置以及当地政府/机构政策的建议。在您的 SRL 中制定新的 COVID 相关政策时，请确保您遵守任何当地颁布的指南并与相关安全官员联络。虽然这些指南中的大多数已被描述为在流式细胞仪 SRL 中实施，它们还更广泛地适用于主要操作模型基于多用户对空间和仪器的访问的任何 SRL 设置。最后，为了遵守新的监管指南，建议在颁布新政策时解释指南背后的基本原理。