Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery,ChemNanoMat

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Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-11-14 , DOI: 10.1002/cnma.202000539
Dandan Wang ₁ , Yuanyuan Zhang ₁ , Mingzhu Zhai ₁ , Yan Huang ₁ , Hui Li ₁ , Xicheng Liu ₁ , Peiwei Gong ₁ , Zhe Liu ₁ , Jinmao You _{1,

2}

Affiliation

Although fluorinated graphene/Fe₃O₄ composites exhibit a unique structure and chemical surface, and thus hold great potential in many fields, their effective synthesis has remained a headache because of poor dispersity and easy aggregation behavior. Herein, we report a novel method to prepare hyaluronic acid (HA)‐modified fluorinated graphene with a well‐defined structure and good solubility in various media, and this then allowed us for the first time to controllably deposit magnetic Fe₃O₄ nanoparticles onto the sheets with designed ratio and contents. This strategy further guaranteed a multifunctional composite that possessed HA and magnetism‐induced dual‐targeting effect towards cancer cells and high near‐infrared absorption for photothermal therapy (PTT). Moreover, this composite also showed an effective turn‐off fluorescence effect for the anticancer drug doxorubicin, allowing us to visually monitor the drug loading procedure. Anticancer experiments indicated that such a successful combination of PTT and chemotherapy with special selectivity toward cancer cells exhibited a much better therapeutic effect than single therapy.

中文翻译：

具有高近红外吸收率的荧光关闭磁性氟化石墨烯复合材料，可用于靶向药物输送

尽管氟化石墨烯/ Fe ₃ O ₄复合材料表现出独特的结构和化学表面，因此在许多领域都具有巨大潜力，但由于分散性差和易于聚集，它们的有效合成仍然令人头疼。本文中，我们报告了一种新颖的方法，该方法可制备结构明确且在各种介质中具有良好溶解性的透明质酸（HA）改性的氟化石墨烯，这使我们首次可控地沉积磁性Fe ₃ O _4。以设计的比例和含量将纳米颗粒沉积到片材上。该策略进一步保证了一种多功能复合材料，该复合材料具有HA和磁性诱导的针对癌细胞的双重靶向作用，并且对光热疗法（PTT）具有很高的近红外吸收率。此外，该复合材料还对抗癌药物阿霉素具有有效的关闭荧光作用，使我们可以目测药物装载过程。抗癌实验表明，PTT和化学疗法的这种成功结合对癌细胞具有特殊的选择性，其治疗效果比单一疗法更好。

更新日期：2021-01-12

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