A detailed chemical and biological investigation of twelve Allium species from Eastern Anatolia with chemometric studies,Chemistry & Biodiversity

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A detailed chemical and biological investigation of twelve Allium species from Eastern Anatolia with chemometric studies
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-12-08 , DOI: 10.1002/cbdv.202000560
Ebubekir Izol _{1,

2} , Hamdi Temel ₁ , Mustafa Abdullah Yilmaz ₁ , Ismail Yener ₁ , Ozge Tokul Olmez ₃ , Erhan Kaplaner ₃ , Mehmet Fırat ₄ , Nesrin Hasimi ₅ , Mehmet Ozturk ₃ , Abdulselam Ertas ₆

Affiliation

Allium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC‐MS/MS. In vitro antioxidant, anticholinesterase, cytotoxic and antimicrobial activities were also tested. The multivariate analyses were performed using principal component and hierarchical cluster analyses. Seventeen of 27 standard compounds were detected in all Allium species. The major components were mainly identified as quinic acid, malic acid, vanillin, and p‐coumaric acid. The aerial parts possessed better antioxidant activity than roots. Aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense exhibited high cytotoxic activity against DLD‐1 colon cancer cell lines (IC50 12.5 μg/mL). A. shatakiense and A. vineale demonstrated good antimicrobial activity against S. aureus and E. coli (MIC 75 μg/mL). According to chemometric analysis, differences were detected between aerial parts and the roots. The aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense could be potent in the pharmaceutical industry while A. shatakiense and A. vineale in the food industry after further investigations.

中文翻译：

通过化学计量学研究对来自东安纳托利亚的十二种葱属进行详细的化学和生物学研究

葱属物种在世界各地被广泛用作食物。使用 LC-MS/MS 研究了从五个不同的东部安纳托利亚地区收集的 12 种葱属植物地上部分和根的乙醇提取物的酚类特征。还测试了体外抗氧化剂、抗胆碱酯酶、细胞毒性和抗菌活性。使用主成分和层次聚类分析进行多变量分析。在所有葱属物种中检测到 27 种标准化合物中的 17 种。主要成分主要为奎宁酸、苹果酸、香兰素和对香豆酸。地上部分比根具有更好的抗氧化活性。A. atroviolaceum、A. chrysantherum、A. kharputense 和 A. shirnakiense 的地上部分对 DLD-1 结肠癌细胞系表现出高细胞毒活性 (IC50 12.5 μg/mL)。A. shatakiense 和 A. vineale 对金黄色葡萄球菌和大肠杆菌表现出良好的抗菌活性（MIC 75 μg/mL）。根据化学计量学分析，在地上部分和根之间检测到差异。经过进一步调查，A. atroviolaceum、A. chrysantherum、A. kharputense 和 A. shirnakiense 的地上部分可能在制药行业中发挥作用，而 A. shatakiense 和 A. vineale 在食品行业中可能是有效的。

更新日期：2020-12-08

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