For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.

中文翻译：

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代谢微环境驱动微生物分化和抗生素耐药性

对于细菌，从单细胞实体到多细胞生物膜群落的过渡产生了独特的代谢微环境。动态的和程序化的代谢反应使生物膜能够对营养水平的局部变化做出反应。此外，代谢适应有助于社区的表型抗生素抗药性，提示了靶向生物膜的新型治疗方法。