This study aimed to analyze the effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) modes in female Wistar rats. 18 Wistar female adult rats were divided into three groups: control (CG), pressure-controlled ventilation (PCVG), and volume-controlled ventilation (VCVG). PCVG and VCVG were submitted to MV for one hour with a tidal volume (TV) of 8 mL/Kg, respiratory rate of 80 breaths/min, and positive end-expiratory pressure of 0 cmH₂O. At the end of the experiment, all animals were euthanized. The neutrophils and lymphocytes influx to lung were higher in VCVG and PCVG compared to CG. The activities of superoxide dismutase, catalase and myeloperoxidase were higher in PCVG compared to CG. There was an increase in lipid peroxidation and protein oxidation in PCVG compared to CG. The levels of CCL3 and CCL5 were higher in PCVG compared to CG. In conclusions, the PCV mode promoted structural changes in the lung parenchyma, redox imbalance and inflammation in healthy adult female rats submitted to MV.

本研究旨在分析容量控制通气 (VCV) 和压力控制通气 (PCV) 模式对雌性 Wistar 大鼠的影响。18只Wistar雌性成年大鼠分为三组：对照组（CG）、压力控制通气（PCVG）和容量控制通气（VCVG）。PCVG 和 VCVG 接受 MV 1 小时，潮气量 (TV) 为 8 mL/Kg，呼吸频率为 80 次/分钟，呼气末正压为 0 cmH ₂O. 在实验结束时，所有动物都被安乐死。与 CG 相比，VCVG 和 PCVG 中中性粒细胞和淋巴细胞流入肺的数量更高。与CG相比，PCVG中超氧化物歧化酶、过氧化氢酶和髓过氧化物酶的活性更高。与 CG 相比，PCVG 中脂质过氧化和蛋白质氧化增加。与 CG 相比，PCVG 中 CCL3 和 CCL5 的水平更高。总之，PCV 模式促进了接受 MV 的健康成年雌性大鼠的肺实质结构变化、氧化还原失衡和炎症。