Research question

Are children born from vitrified-warmed oocytes physically or mentally different from naturally conceived children?

Design

Intracytoplasmic sperm injection (ICSI) of vitrified-warmed oocytes was performed for 282 patients (307 cycles) from August 2000 to March 2020. Long-term follow-up of children born from vitrified-warmed oocytes was performed via a questionnaire that was sent to the parents at regular intervals from 3 to 72 months after the child's birth. Questionnaires were sent 11 times from birth to the age of 6 years. The development of motor function and mental status was evaluated as the primary outcome, based on the reported data. Subsequently, patients were divided into four groups by age at oocyte retrieval (20–29, 30–34, 35–39, and 40 years or older). Clinical outcomes were calculated as a secondary outcome.

Results

For the 282 patients, the birth of 116 babies was reported (110 singletons and three sets of twins), and seven cases are, at the time of writing, unconfirmed. The results of the survey found physical parameters in singletons to be equivalent to the nationally reported average data issued by the Ministry of Health, Labor and Welfare of Japan.

Conclusion

This is the first follow-up report of children born from vitrified-warmed oocytes followed by ICSI. The data suggested that the responses from the study participants on the mental and physical development of children were comparable to the data reported by the government, although more responses from patients should be collected to allow further study.

中文翻译：

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玻璃化冷冻卵子出生儿童的六年随访

研究问题

玻璃化加热卵母细胞所生的孩子与自然受孕的孩子在生理或心理上是否不同？

设计

2000 年 8 月至 2020 年 3 月，对 282 名患者（307 个周期）进行了玻璃化加热卵母细胞胞浆内单精子注射（ICSI）。父母在孩子出生后 3 至 72 个月内定期检查。问卷从出生到 6 岁共发送 11 次。根据报告的数据，运动功能和精神状态的发展被评估为主要结果。随后，患者按取卵年龄分为四组（20-29、30-34、35-39 和 40 岁或以上）。临床结果被计算为次要结果。

结果

在这 282 名患者中，报告了 116 名婴儿的出生（110 名单胎和三对双胞胎），在撰写本文时，有 7 例尚未确诊。调查结果发现，单身人士的身体参数与日本厚生劳动省发布的全国报告平均数据相当。

结论

这是从玻璃化加热的卵母细胞出生的儿童的第一份后续报告，随后是 ICSI。数据表明，研究参与者对儿童身心发展的反应与政府报告的数据相当，但应收集更多患者的反应以进行进一步研究。