Chitosan nanoparticles (CSNPs) have been recently explored as a potential drug carrier to enhance the bioavailability and aqueous solubility of drugs. Curcumin, an antioxidant with a remarkable antiradical scavenging activity was encapsulated in CSNPs to revamp its bioavailability. While changes in the optimal farming condition can induce oxidative stress in the animals, curcumin loaded chitosan nanoparticles (Cur-CSNPs) were amalgamated into shrimp feed pellets to ameliorate its antioxidant content in an attempt to bolster the organisms against oxidative stress. Cur-CSNPs were synthesized in two different concentrations of curcumin as Cur-CSNPs A and B. Characterization of the synthesized Cur-CSNPs revealed asymmetrical nanoparticles with semispherical geometry and a zeta potential ˃50 mV. HPLC studies substantiated encapsulation efficiencies of 77.53% and 80.35% for Cur-CSNPs A and B respectively. DPPH, ABTS and FRAP assays manifested a significant enhancement in the antioxidant property of the Cur-CSNPs fortified feed pellets. This is the first study to investigate and demonstrate the ability of Cur-CSNPs to enhance the antioxidant property of aquaculture feed pellets. These findings substantiate that Cur-CSNPs fortified feed may be applied to reinforce aquaculture animals against oxidative stress.

壳聚糖纳米颗粒（CSNPs）最近已被探索为一种潜在的药物载体，可以增强药物的生物利用度和水溶性。姜黄素是一种具有显着抗自由基清除活性的抗氧化剂，被包裹在CSNP中以改善其生物利用度。虽然最佳饲养条件的变化会引起动物氧化应激，但将姜黄素负载的壳聚糖纳米颗粒（Cur-CSNPs）合并为虾饲料颗粒，以改善其抗氧化剂含量，以试图增强生物体抵抗氧化应激的能力。在两种不同浓度的姜黄素中分别以Cur-CSNPs A和B的形式合成了Cur-CSNPs。合成的Cur-CSNPs的表征显示具有半球形几何形状和zeta˃50mV的不对称纳米颗粒。HPLC研究证实，Cur-CSNPs A和B的包封效率分别为77.53％和80.35％。DPPH，ABTS和FRAP分析表明，Cur-CSNPs强化饲料颗粒的抗氧化性能显着增强。这是第一个研究和证明Cur-CSNPs增强水产饲料颗粒抗氧化性能的研究。这些发现证实，Cur-CSNPs强化饲料可用于增强水产养殖动物抵抗氧化应激。