In this study, hexachlorocyclotriphosphazene (HCCP) and tannic acid (TA) were used at different stoichiometric rates to synthesize cyclomatrix-type polymeric materials with different surface features and dimensions. Using different reactive ratios, the structure and surface functional groups of the synthesized polymeric particles were explained using Fourier-Transform Infrared Spectroscopic (FTIR), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray Photoelectron Spectroscopy (XPS) and Thermogravimetric (TG) analysis techniques. With morphologically fully spherical structure and mean 234.82 ± 49.37 nm dimensions, Phz-TA (4:1) nanospheres were researched for in vitro biodegradability, antioxidant features, and usability as a drug release system. In vitro biodegradability of Phz-TA (4:1) nanospheres was investigated at pH=7.0 and pH=1.2. Determined to degrade in 8-10 hours at these pH values, nanospheres were used for releasing of Rhodamine 6G as a model drug. Due to the rich phenolic structure of the contained tannic acid units, nanospheres were determined to simultaneously have antioxidant features. Thus, this study determined that Phz-TA nanospheres with in vitro biodegradability and antioxidant features are promising polymeric materials for use as a potential drug-carrier in the future.

在这项研究中，六氯环三磷腈（HCCP）和单宁酸（TA）用于不同的化学计量比，以合成具有不同表面特征和尺寸的环基质型聚合物材料。使用不同的反应比，通过傅立叶变换红外光谱（FTIR），扫描电子显微镜（SEM），能量色散X射线光谱（EDX），X射线光电子解释了合成的聚合物颗粒的结构和表面官能团光谱（XPS）和热重（TG）分析技术。Phz-TA（4：1）纳米球具有形态学上完整的球形结构，平均尺寸为234.82±49.37 nm，具有体外生物降解性，抗氧化剂特性以及作为药物释放系统的可用性，因此得到了研究。体外在pH = 7.0和pH = 1.2的条件下研究了Phz-TA（4：1）纳米球的生物降解性。确定在这些pH值下可在8-10小时内降解，纳米球用于释放若丹明6G作为模型药物。由于所含鞣酸单元的酚结构丰富，因此确定纳米球同时具有抗氧化功能。因此，这项研究确定了具有体外生物降解性和抗氧化剂特性的Phz-TA纳米球是有希望的高分子材料，将来有望用作潜在的药物载体。