Abstract Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 μm pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration.

中文翻译：

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通过 3D 打印聚（乙醇酸）/羟基磷灰石复合支架促进骨再生

摘要 羟基磷灰石（HAp）是硬组织再生的主要骨移植成分。然而，烧结HAp具有较差的可成形性和机械性能。用于骨组织再生的多孔 3D 支架使用聚（乙醇酸）（PGA）和 HAp 通过计算机辅助建模打印。含有 HAp 纳米粒子的 PGA 支架被制造为具有 400 μm 的孔径。含有 12.5% HAp 的 PGA/HAp 支架显示出相当大的抗压强度、成骨、矿化和生物降解。在体内动物实验中，PGA/HAp 组在手术后 8 周表现出 47% 的骨再生率和优越的骨密度。3D 打印的 PGA/HAp 支架可以提供一种可行的选择来促进患者特定的骨再生。