There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clusters—hubs—of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity.

在过去十年中，我们对转录调控的看法发生了翻天覆地的变化（Fukaya et al. , 2016, Lim et al. , 2018, Hnisz et al. , 2017 [3], Liu et al. , 2018 [4] ，加藤等人，2012）。增强子-启动子相互作用的经典模型和单个 RNA 聚合酶 II (Pol II) 复合物的逐步组装已经让位于活性转录灶包含转录激活因子和 Pol II 的簇（集线器）的认识。在这里，我们总结了最近的发现，这些发现指出了转录中心的出现以及这些中心对基因活性调节的影响。