Updates of the mosaic fluid membrane model implicitly sustain the paradigms that bilayers are closed systems conserving a state of fluidity and behaving as a dielectric slab. All of them are a consequence of disregarding water as part of the membrane structure and its essential role in the thermodynamics and kinetics of membrane response to bioeffectors.

A correlation of the thermodynamic properties with the structural features of water makes possible to introduce the lipid membrane as a responsive structure due to the relaxation of water rearrangements in the kinetics of bioeffectors' interactions.

This analysis concludes that the lipid membranes are open systems and, according to thermodynamic of irreversible formalism, bilayers and monolayers can be reasonable compared under controlled conditions. The inclusion of water in the complex structure makes feasible to reconsider the concept of dielectric slab and fluidity.

镶嵌流体膜模型的更新隐含了这样的范例：双层是封闭的系统，既保持了流动性，又表现为电介质平板。所有这些都是忽略水作为膜结构的一部分及其在膜对生物效应物的热力学和动力学中的重要作用的结果。

热力学性质与水的结构特征之间的相关性使得可以将脂质膜作为响应性结构引入，这是由于在生物效应子相互作用的动力学中水重排的松弛。

该分析得出的结论是，脂质膜是开放系统，根据不可逆形式主义的热力学，双层和单层可以在受控条件下比较合理。在复杂结构中包含水使得重新考虑介电平板和流动性的概念变得可行。