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Highly Fluorescent Doped Fe 3 O 4 @C Nanoparticles Cross the Blood–Brain Barrier: Help in Brain Imaging and Blocking the Life Cycle of Mosquitoes
Journal of Cluster Science ( IF 2.7 ) Pub Date : 2020-11-14 , DOI: 10.1007/s10876-020-01938-w
Nargish Parvin , Tapas K. Mandal , P. C. Nagajyothi , P. Mohan Reddy , N. Ramesh Reddy , Sang W. Joo

Day by day, humans and animals are infected with life-threatening and deadly diseases due to mosquito bites. Current methods used to fight these diseases are not fully viable and unsafe for humans and animals. Controlling the germ-carrying mosquitoes requires the immediate transfer of a conceptual paradigm. This experiment suggested a safe mosquito control mechanism with fluorescence iron-oxide core carbon-coated (f-Fe3O4@C) nontoxic nanoparticles used as an active agent. As the concept of experiment, we chose mosquitoes of Anopheles, Aedes, and Culex genera because they are found worldwide and infect pathogens. The progression of the life cycle of mosquitoes was observed and imaging under the treated known concentration of f-Fe3O4@C nanoparticles. Resulted that a minimum 3 mg/L and above concentration of f-Fe3O4@C nanoparticles in breeding water these group of larvae can’t attend their adulthood and ultimately died under prolong stay in the larval stage. In this case, though the species can be studied for a sustained time the originality of the wild species is lost.



中文翻译:

高度掺杂荧光的Fe 3 O 4 @C纳米颗粒穿过血脑屏障:有助于大脑成像并阻止蚊子的生命周期

每天,由于蚊虫叮咬,人类和动物感染了威胁生命的致命疾病。当前用于对抗这些疾病的方法对于人类和动物而言并不完全可行且不安全。控制携带细菌的蚊子需要立即转移概念范式。该实验提出了一种安全的蚊虫控制机制,该方法使用了荧光氧化铁芯碳包覆的(f-Fe 3 O 4 @C)无毒纳米颗粒作为活性剂。作为实验的概念,我们选择了按蚊,伊蚊库蚊属的蚊子,因为它们在世界各地都有发现并感染病原体。在已知的f-Fe浓度下观察到蚊子生命周期的进展并进行成像3 O 4 @C纳米粒子。结果表明,在繁殖水中,至少3 mg / L或以上的f-Fe 3 O 4 @C纳米颗粒浓度,这些组幼虫不能成年,最终在长期停留在幼虫阶段死亡。在这种情况下,尽管可以持续研究该物种,但野生物种的独创性消失了。

更新日期:2020-11-15
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