Monitoring of food contaminants and residues has undergone a significant improvement in recent years and is now performed in an intensive manner. Achievements in the area of chromatography-mass spectrometry coupling techniques enabled the development of quantitative multi-target approaches covering several hundred analytes. Although the majority of methods are focusing on the analysis of one specific group of substances, such as pesticides, mycotoxins, or veterinary drugs, current trends are going towards the simultaneous determination of multiclass compounds from several families of contaminants and residues. This work provides an overview of relevant multiclass concepts based on LC-MS/MS and LC-HRMS instruments. Merits and shortcomings will be critically discussed based on current performance characteristics of the EU legislation system. In addition, the discussion of a recently developed multiclass approach covering >1000 substances is presented as a case study to illustrate the current developments in this area.

近年来，食品污染物和残留物的监测有了显着改进，现在正在以密集的方式进行。色谱-质谱联用技术领域的成就使得能够开发涵盖数百种分析物的定量多目标方法。尽管大多数方法都侧重于分析一组特定的物质，例如农药、霉菌毒素或兽药，但当前的趋势是同时测定来自多个污染物和残留物家族的多类化合物。这项工作概述了基于 LC-MS/MS 和 LC-HRMS 仪器的相关多类概念。将根据欧盟立法体系当前的绩效特征，批判性地讨论优点和缺点。此外，还以案例研究的形式讨论了最近开发的涵盖 >1000 物质的多类方法，以说明该领域的当前发展。