A gold(I)-catalyzed novel domino reaction of acyclic ynamides yielding nitrogen-fused bicyclic skeletons was described. The reaction with 10 mol% JohnPhosAuNTf2 and stoichiometric amount of PhCO2H enables constructions of quinolizidine and indolizidine skeleton having tetrasubstituted carbon center. Especially in the case of quinolizidine synthesis, the quaternary stereogenic center could be furnished under highly diastereoselective manner.

中文翻译：

---

从头到尾通过金催化的水胺化处理联氮的方法–

描述了金（I）催化的无环炔酰胺的新型多米诺反应，该反应产生了氮稠合的双环骨架。通过与10mol％的JohnPhosAuNTf 2和化学计量的PhCO 2 H进行反应，可以构建具有四取代碳中心的喹嗪和吲哚并嗪骨架。特别是在喹喔啉合成的情况下，可以高度非对映选择性的方式提供四级立体异构中心。