Organ-dedicated PET scanners are becoming more prevalent because of their advantages in higher sensitivity, improved image quality, and lower cost. Detectors utilized in these scanners have finer pixel size with depth of interaction (DOI) capability. This work presents a LYSO(Ce) detector module with DOI capability which has the potential to be scaled up to a high-resolution small animal or organ-dedicated PET system. For DOI capability, a submodule with one LYSO block detector utilizing PETsys TOFPET2 application-specific integrated circuit (ASIC) was previously developed in our lab. We scaled up the submodule and optimized the configuration to allow for a compact housing of the dual-readout boards in one side of the blocks by designing a high-speed dual-readout cable to maintain the original pin-to-pin relationship between the Samtec connectors. The module size is 53.8נ57.8 mm². Each module has 2נ2 LYSO blocks, each LYSO block consists of 4נ4 LYSO units, and each LYSO unit contains a 6נ6 array of 1נ1נ20 mm³ LYSO crystals. The four lateral surfaces of LYSO crystal were mechanically ground to W14, and the two end surfaces were polished. Two ends of the LYSO crystal are optically connected to SiPM for DOI measurement. Eight LYSO blocks performance including energy, timing, and DOI resolution is characterized with a single LYSO slab. The in-panel and orthogonal-panel spatial resolution of the two modules with 107.4 mm distance between each other are measured at 9 positions within the field of view (FOV) with a ²²Na source. Results show that the average energy, timing, and DOI resolution of all LYSO blocks are 16.13%1.01% at 511 keV, 658.0315.18 ps, and 2.620.06 mm, respectively. The energy and timing resolution of two modules are 16.35% and 0.86 ns, respectively. The in-panel and orthogonal-panel spatial resolution of the two modules at the FOV center are 1.9 and 4.4 mm respectively.

器官专用 PET 扫描仪因其灵敏度更高、图像质量更高和成本更低等优点而变得越来越普遍。这些扫描仪中使用的探测器具有更精细的像素尺寸和交互深度 (DOI) 功能。这项工作提出了一种具有 DOI 功能的 LYSO(Ce) 探测器模块，该模块有可能扩展到高分辨率小动物或器官专用 PET 系统。对于 DOI 功能，我们的实验室之前开发了一个带有 LYSO 块探测器的子模块，该子模块利用 PETsys TOFPET2 专用集成电路 (ASIC)。我们扩大了子模块的规模并优化了配置，通过设计高速双读出电缆来保持 Samtec 之间的原始引脚对引脚关系，以便在模块的一侧实现双读出板的紧凑外壳。连接器。模块尺寸为53.8×57.8 mm ² 。每个模块有2×2个LYSO块，每个LYSO块由4×4个LYSO单元组成，每个LYSO单元包含1×1×20 mm ³ LYSO晶体的6×6阵列。 LYSO晶体的四个侧面机械研磨至W14，两端面抛光。 LYSO 晶体的两端光学连接到 SiPM 以进行 DOI 测量。八个 LYSO 块的性能（包括能量、计时和 DOI 分辨率）通过单个 LYSO 板进行表征。使用²² Na 源在视场 (FOV) 内的 9 个位置测量两个彼此距离为 107.4 mm 的模块的面板内和正交面板空间分辨率。结果表明，所有 LYSO 模块在 511 keV、658.0315.18 ps 和 2.620.06 mm 时的平均能量、定时和 DOI 分辨率分别为 16.13%1.01%。 两个模块的能量分辨率和时间分辨率分别为16.35%和0.86 ns。两个模块在FOV中心的面板内和正交面板空间分辨率分别为1.9和4.4毫米。