The aqueous methanolic extract of Andira inermis(A. inermis) stem bark was screened for phytochemical constituents, antioxidant activity, acute oral toxicity, and preliminary prophylactic normoglycaemic test and effect on Oral Glucose Tolerance in albino rats. Andira inermis was double macerated and extracted with 80% methanol. Phytochemical analysis and acute toxicity were performed using standard methods. The extract was screened for in vitro antioxidant activity using Ferric Reducing/Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging spectrophotometric assays. Prophylactic control of glucose was evaluated in normoglycaemic and glucose-challenged albino rats. Graded test doses (100–400 mg/kg body weight) of the extract were used in the investigation. The effects observed were compared with that of glibenclamide (0.2 mg/kg) and distilled water control groups. The stem bark extract of A. inermis was found to contain saponins, terpenes, tannins, steroids, flavanoids, anthraquinones, carbohydrates and alkaloids. The extract was found to have a significant in vitro antioxidant activity in both methods. The oral acute toxicity study showed the extract had LD50 greater than 5000 mg/kg. The extract significantly (p ≤ 0.05) reduced blood glucose levels in normoglycaemic animal model (the control group seen to have − 5.6(− 8.7%) poor glucose handling; and the glibenclamide& extract treatment group (100 mg/kg) to positively reduce blood glucose 14.8(26.8%) & 16.4(25.9%) respectively). The glucose challenged test, from the 1st hour, showed − 57.4(− 89.4%),-26.8(− 33.8%),-23.8(− 26.3%),-12.8(− 13.9%) and − 9.8(− 10.4%) for the vehicle control, glibenclamide (positive control), and the 100, 200 & 400 mg/kg extract treatment groups respectively. The extract showed mild hypoglycemic effect in the results recorded, up to the 4th hour. The results of this study elucidated that the aqueous methanolic extract of Andira inermis stem bark possessed potent antioxidant phyto-constituents with potential hypoglycaemic effects that could be explored for therapeutic use worldwide following isolation and characterization of the bioactive principles. And the results also authenticate the folklore use of the plant.

中文翻译：

---

评价Andira麦为低血糖干树皮提取物和抗氧化作用

筛选无定形雄蕊（A. inermis）茎皮的甲醇提取物的植物化学成分，抗氧化活性，急性口服毒性，初步预防性降血糖试验以及对白化病大鼠口服葡萄糖耐量的影响。将Andira inermis浸软，并用80％甲醇萃取。使用标准方法进行植物化学分析和急性毒性。使用三价铁还原/抗氧化能力（FRAP）和2,2-二苯基-1-吡啶并肼基（DPPH）自由基清除分光光度法筛选提取物的体外抗氧化活性。在正常血糖和葡萄糖挑战的白化病大鼠中评估了葡萄糖的预防性控制。提取物中的分级测试剂量（100-400 mg / kg体重）用于研究。将观察到的效果与格列本脲（0.2 mg / kg）和蒸馏水对照组的效果进行了比较。发现无铁曲霉的茎皮提取物含有皂苷，萜烯，丹宁酸，类固醇，类黄酮，蒽醌，碳水化合物和生物碱。发现在两种方法中提取物均具有显着的体外抗氧化活性。口服急性毒性研究表明，该提取物的LD50大于5000 mg / kg。提取物显着（p≤0.05）降低了正常血糖动物模型中的血糖水平（对照组的葡萄糖处理能力降低了-5.6（-8.7％）；而格列苯脲和提取物治疗组（100 mg / kg）则积极降低了血液葡萄糖分别为14.8（26.8％）和16.4（25.9％））。从第一小时开始的葡萄糖激发试验显示-57.4（-89.4％），-26.8（-33.8％），-23.8（-26.3％），-12.8（-13。媒介物对照，格列本脲（阳性对照）以及100、200和400 mg / kg提取物治疗组分别为9％）和-9.8（-10.4％）。提取物在记录的结果中显示出轻微的降血糖作用，直至第4小时。这项研究的结果表明，无定形雄蕊树皮的甲醇提取物具有有效的降血糖作用，并且具有潜在的降血糖作用，可以通过生物活性成分的分离和表征在世界范围内进行治疗。结果还证明了该植物的民俗用途。这项研究的结果表明，无定形雄蕊树皮的甲醇提取物具有有效的降血糖作用，并且具有潜在的降血糖作用，可以通过生物活性成分的分离和表征在世界范围内进行治疗。结果还证明了该植物的民俗用途。这项研究的结果表明，无定形雄蕊树皮的甲醇提取物具有有效的降血糖作用，并且具有潜在的降血糖作用，可以通过生物活性成分的分离和表征在世界范围内进行治疗。结果还证明了该植物的民俗用途。