Recycling of two molecular catalysts in the hydroformylation/aldol condensation tandem reaction using one multiphase system,Green Chemistry

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Recycling of two molecular catalysts in the hydroformylation/aldol condensation tandem reaction using one multiphase system
Green Chemistry ( IF 9.3 ) Pub Date : 2020-11-06 , DOI: 10.1039/d0gc03392h
Marc Strohmann _{1,

2,

3} , Jeroen T. Vossen _{1,

2,

3} , Andreas J. Vorholt _{1,

2,

3} , Walter Leitner _{1,

2,

3,

4,

5}

Affiliation

Tandem reactions are of great importance to efficiently execute multiple conversions in one synthesis step. Herein we present a multiphase system for the hydroformylation/aldol condensation, which is able to recycle both optimized catalysts multiple times. The system consists of an organometallic rhodium/sulfoXantphos hydroformylation catalyst and basic NaOH as aldol condensation initiator, which are both immobilized in a polyethylene glycol phase. Under reaction conditions, NaOH is converted to sodium formate, which is still able to catalyse the aldol condensation. The reaction and recycling are demonstrated by the conversion of 1-pentene to the corresponding aldol product in a recycling experiment. During nine consecutive runs, no significant loss of activity is found with an overall TON of 8700 in regard to the rhodium catalyst and an average rhodium leaching of only of 0.07% per run is observed.

中文翻译：

使用一个多相系统在加氢甲酰化/羟醛缩合串联反应中回收两种分子催化剂

串联反应对于在一个合成步骤中有效执行多次转化非常重要。本文中，我们提出了一种用于加氢甲酰化/羟醛缩合的多相系统，该系统能够多次循环使用两种优化的催化剂。该系统由有机金属铑/磺基黄磷加氢甲酰化催化剂和碱性NaOH作为醇醛缩合引发剂组成，两者均固定在聚乙二醇相中。在反应条件下，NaOH转化为甲酸钠，仍然能够催化羟醛缩合。通过在再循环实验中将1-戊烯转化为相应的羟醛产物来证明反应和再循环。在连续九次跑步中，

更新日期：2020-11-13

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