Flavors in electronic cigarette (ECIG) liquids may increase ECIG aerosol toxicity via intact distillation or chemical transformation. For this report, we performed a meta-analysis of the literature to categorize the compounds found in flavored ECIG liquids into a few chemical classes and to predict their possible chemical transformations upon ECIG liquid aerosolization. This analysis allowed us to propose specific correlations between flavoring chemicals and aerosol toxicants. A literature search was conducted in November 2019 using PubMed. Keywords included terms related to ECIGs and flavors. Studies were included if they reported chemical ingredients of flavored liquids and clearly stated the commercial names of these liquids. The obtained data were visualized on a network diagram to show the common chemical compounds identified in flavored ECIG liquids and categorize them into different chemical classes. The systematic literature review included a total of 11 articles. Analysis of the data reported gave a total of 189 flavored liquids and 173 distinct chemical compounds that were categorized into 22 chemical classes according to their functional groups. The subsequent prediction of chemical transformations of these functional groups highlighted the possible correlation of flavor compounds to aerosol toxicants.

中文翻译：

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电子烟中风味毒物的相关性：荟萃分析

电子烟 (ECIG) 液体中的香料可能会通过完整蒸馏或化学转化增加 ECIG 气溶胶毒性。在本报告中，我们对文献进行了荟萃分析，将调味 ECIG 液体中发现的化合物分为几个化学类别，并预测它们在 ECIG 液体雾化后可能发生的化学转化。这种分析使我们能够提出调味化学品和气溶胶毒物之间的特定相关性。2019 年 11 月使用 PubMed 进行了文献检索。关键字包括与 ECIG 和风味相关的术语。如果研究报告了调味液体的化学成分并清楚地说明了这些液体的商业名称，则包括在内。获得的数据在网络图上可视化，以显示在调味 ECIG 液体中识别的常见化合物，并将它们归类为不同的化学类别。系统文献综述共收录 11 篇文章。对报告数据的分析给出了总共 189 种调味液体和 173 种不同的化合物，这些化合物根据其官能团分为 22 个化学类别。随后对这些官能团化学转化的预测强调了风味化合物与气溶胶毒物之间可能存在的相关性。对报告数据的分析给出了总共 189 种调味液体和 173 种不同的化合物，这些化合物根据其官能团分为 22 个化学类别。随后对这些官能团化学转化的预测强调了风味化合物与气溶胶毒物之间可能存在的相关性。对报告数据的分析给出了总共 189 种调味液体和 173 种不同的化合物，这些化合物根据其官能团分为 22 个化学类别。随后对这些官能团化学转化的预测强调了风味化合物与气溶胶毒物之间可能存在的相关性。