Abstract The influence of coating a CdTe quantum dots (QDs) layer on the 198Au nanoparticles (NPs) in biodistribution of 198Au nanoparticles was investigated. The 198Au nanoparticles were prepared by irradiating the highly pure metallic gold in Tehran research nuclear reactor and subsequently 198Au-NPs were synthesized and subjected to surface modification with cysteamine and CdTe QDs to form an adduct. The prepared nanomaterials were characterized with X-ray diffraction, radio thin layer chromatography, transmission electron microscopy, and scanning electron microscopy. In-vivo biodistribution and tumor avidity studies were performed by intravenously injecting of cysteamine@198AuNPs: CdTe QDs nanocomposite into rats. The %ID/g (percent of the initial dose per gram tissue weight) in dissected organs and Fibrosarcoma tumor specimens was then measured. The hydrophilicity of the cysteamine@198AuNPs was increased by surface modification with CdTe QDs. Rapid excretion from body and high tumor uptake for cysteamine@198AuNPs: CdTe QDs revealed that this radiotracer could potentially be used in nuclear medicine as a theranostic agent.

中文翻译：

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金 198 纳米颗粒上的 CdTe 量子点：引入新型治疗诊断剂

摘要 研究了在 198Au 纳米粒子 (NPs) 上涂覆 CdTe 量子点 (QD) 层对 198Au 纳米粒子的生物分布的影响。通过在德黑兰研究核反应堆中辐照高纯金属金制备 198Au 纳米粒子，随后合成 198Au-NPs 并用半胱胺和 CdTe 量子点进行表面改性以形成加合物。用X射线衍射、无线电薄层色谱、透射电子显微镜和扫描电子显微镜对制备的纳米材料进行了表征。通过向大鼠静脉注射半胱胺@198AuNPs：CdTe QDs 纳米复合材料进行体内生物分布和肿瘤亲和力研究。然后测量解剖器官和纤维肉瘤肿瘤标本中的 %ID/g（每克组织重量的初始剂量百分比）。半胱胺@198AuNPs 的亲水性通过用 CdTe QDs 进行表面改性而增加。半胱胺@198AuNPs 从体内快速排泄和高肿瘤吸收：CdTe QD 显示这种放射性示踪剂有可能在核医学中用作治疗诊断剂。