Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area.

生物偶联反应在产生修饰的肽和蛋白质方面起着重要的促进作用。该领域的早期进展受到底物范围有限和生物偶联试剂相对较差的生物相容性等挑战的阻碍。然而，最近在可见光诱导的光氧化还原催化和电化学催化反应方面的发展已经允许在合成和生物共轭化学领域开发重要的新型反应性。这一观点描述了主要通过单电子转移 (SET) 过程使用生物相容性能量输入修饰肽和蛋白质的最新进展，以及该领域未来的关键发展。