ABSTRACT

Background: To investigate the association of polypharmacy with physical function, nutritional status, and depression in the elderly.

Method: The study included 675 people aged over 65 years from 8 centers in various geographical regions. The polypharmacy status was categorized as non-polypharmacy (0–4 drugs), polypharmacy (≥5 drugs). The subjects’ physical function was assessed based on their “physical activity levels, Holden ambulation scores, gait speeds, and hand grip strengths”; their nutritional status based on the “Mini Nutritional Assessment (MNA)”; and their psychological status based on the “Center for Epidemiologic Studies Depression Scale -CES-D”.

Results: The presence of polypharmacy in this population was found to be 30% (n = 203). A statistically significant difference was found between the groups on the level of physical activity, Holden ambulation score, and nutrition status (p < .05). There was a statistically significant difference between the groups also on hand grip strength, MNA score, Charlson score (p < .05).

Conclusion: Polypharmacy was observed to have a significant association with physical function, nutrition, and depression in the elderly aged ≥ 65 years.

摘要

背景：探讨多元药物与老年人的身体功能，营养状况和抑郁症的关系。

方法：该研究包括来自不同地理区域的8个中心的675岁以上65岁以上的人。多药状态分为非多药（0–4种药物），多药（≥5种药物）。根据受试者的“身体活动水平，霍顿运动评分，步态速度和握力”评估其身体功能；根据“迷你营养评估（MNA）”的营养状况；和他们的心理状态基于“流行病学研究中心抑郁量表-CES-D”。

结果：该人群中存在多药店的比例为30％（n = 203）。两组之间在体育活动水平，霍顿运动评分和营养状况方面存在统计学差异（p <.05）。两组之间的握力，MNA评分，Charlson评分也有统计学差异（p <.05）。

结论：在65岁以上的老年人中，观察到多元药物与身体功能，营养和抑郁症有显着相关性。