Abstract

Objective

To evaluate if the preoperative neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are predictive in discriminating between Ta and T1 tumors in aging male patients.

Methods

We retrospectively evaluated 240 male patient data who were ≥ 65 years old, diagnosed primary non-muscle invasive bladder cancer (NMIBC) with transurethral resection between 2008 and 2020. The patients were divided into the two groups according to the pathological stage, which has a stage of Ta defined group 1 and stage of T1 defined group 2. Before the transurethral resection, serum levels of NLR and PLR were obtained from each patient and compared between the groups.

Results

About 115 patients enrolled in group 1 (pTa patients) and 106 patients enrolled in group 2 (pT1 patients). The median age was 73 years (range 65–89) in group 1 and 75 years (range 65–98) in group 2. In complete blood cell (CBC) parameters, neutrophil count, NLR and PLR were higher and lymphocyte count was lower in group 2. There was no statistical difference in leukocyte and platelet counts between groups.

Conclusion

The present study revealed that higher preoperative NLR and PLR were associated with lamina propria invasion in aging male patients with BC and the results have predictive value.

中文翻译：

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术前中性粒细胞/淋巴细胞比率和血小板/淋巴细胞比率是否可以预测老年患者的固有层浸润？

摘要

客观的

评估术前中性粒细胞/淋巴细胞比率 (NLR) 和血小板/淋巴细胞比率 (PLR) 在区分老年男性患者的 Ta 和 T1 肿瘤方面是否具有预测性。

方法

我们回顾性评估了2008年至2020年间240例≥65岁、经尿道电切术诊断为原发性非肌层浸润性膀胱癌（NMIBC）的男性患者资料。根据病理分期将患者分为两组，其中Ta分期定义为第1组，T1分期定义为第2组。在经尿道切除术前，获取每位患者的血清NLR和PLR水平并进行组间比较。

结果

大约 115 名患者参加了第 1 组（pTa 患者）和 106 名患者参加了第 2 组（pT1 患者）。第 1 组和第 2 组的中位年龄分别为 73 岁（范围 65-89）和 75 岁（范围 65-98）。在全血细胞 (CBC) 参数中，中性粒细胞计数、NLR 和 PLR 较高，淋巴细胞计数较低2组。白细胞和血小板计数组间差异无统计学意义。

结论

本研究表明，较高的术前 NLR 和 PLR 与老年男性 BC 患者固有层浸润相关，结果具有预测价值。