Binge alcohol consumption elicits acute and robust increases of muscle sympathetic nerve activity (MSNA), yet the impact of evening binge drinking on morning-after MSNA is unknown. The present study examined the effects of evening binge alcohol consumption on polysomnographic sleep and morning-after MSNA. We hypothesized that evening binge drinking (i.e. 4-5 drink equivalent in <2hrs) would reduce sleep quality and increase morning-after blood pressure (BP) and MSNA. Following a familiarization night within the sleep laboratory, twenty-two participants (12 men, 10 women; 25±1 years) were examined after simulated binge drinking or fluid control (randomized, crossover design). Morning MSNA was successfully recorded across both conditions in 16 participants (8 men, 8 women) during a 10-minute baseline and three Valsalva's maneuvers (VM). Binge drinking reduced rapid eye movement (REM) sleep (15±1 vs. 20±1%; p=0.003), increased stage II sleep (54±1 vs. 51±1%; p=0.002), increased total urine output (2.9±0.2 vs. 2.1±0.1 liters; p<0.001), but did not alter morning-after urine specific gravity. Binge drinking increased morning-after heart rate (65 (54-72) vs. 58 (51-67) beats/min; p=0.013), but not resting BP or MSNA. Binge drinking elicited greater sympathoexcitation during VM (38±3 vs. 43±3 bursts/min, p=0.036). Binge drinking augmented heart rate (p=0.002), systolic BP (p=0.022) and diastolic (p=0.037) BP reactivity to VM phase IV, and blunted cardiovagal baroreflex sensitivity during VM phases II (p=0.028) and IV (p=0.043). In conclusion, evening binge alcohol consumption disrupted REM sleep and morning-after autonomic function. These findings provide new mechanistic insight into the potential role of binge drinking on cardiovascular risk.

中文翻译：

---

晚上酗酒后早晨交感神经活动


暴饮暴食会引起肌肉交感神经活动 (MSNA) 急剧而强劲的增加，但晚上暴饮对早晨 MSNA 的影响尚不清楚。本研究探讨了晚上暴饮暴食对多导睡眠和晨后 MSNA 的影响。我们假设晚上暴饮暴食（即 <2 小时内喝 4-5 杯当量）会降低睡眠质量并增加晨后血压 (BP) 和 MSNA。在睡眠实验室进行熟悉之夜后，22 名参与者（12 名男性，10 名女性；25±1 岁）在模拟酗酒或液体控制（随机、交叉设计）后接受了检查。 16 名参与者（8 名男性，8 名女性）在 10 分钟基线和 3 次 Valsalva 动作 (VM) 期间成功记录了这两种情况的早晨 MSNA。酗酒会减少快速眼动 (REM) 睡眠（15±1 vs. 20±1%；p=0.003），增加 II 期睡眠（54±1 vs. 51±1%；p=0.002），总尿量增加（2.9±0.2 vs. 2.1±0.1 升；p<0.001），但不会改变晨后尿比重。暴饮暴食会增加晨后心率（65 (54-72) 次/分钟 vs. 58 (51-67) 次/分钟；p=0.013），但不会增加静息血压或 MSNA。 VM期间暴饮暴食会引起更大的交感神经兴奋（38±3 vs. 43±3 爆发/分钟，p=0.036）。酗酒会增加心率 (p=0.002)、收缩压 (p=0.022) 和舒张压 (p=0.037) 对 VM IV 期的血压反应性，并减弱 VM II 期 (p=0.028) 和 IV (p) 期间的心血管压力反射敏感性=0.043）。总之，晚上暴饮暴食会扰乱快速眼动睡眠和晨后自主神经功能。这些发现为暴饮暴食对心血管风险的潜在作用提供了新的机制见解。