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Morning Sympathetic Activity after Evening Binge Alcohol Consumption
American Journal of Physiology-Heart and Circulatory Physiology ( IF 4.1 ) Pub Date : 2020-11-13 , DOI: 10.1152/ajpheart.00743.2020
Ian M Greenlund 1, 2 , Hannah A Cunningham 3 , Anne L Tikkanen 2, 3 , Jeremy A Bigalke 1, 2 , Carl A Smoot 3 , John J Durocher 2, 4 , Jason R Carter 1, 2, 3
Affiliation  

Binge alcohol consumption elicits acute and robust increases of muscle sympathetic nerve activity (MSNA), yet the impact of evening binge drinking on morning-after MSNA is unknown. The present study examined the effects of evening binge alcohol consumption on polysomnographic sleep and morning-after MSNA. We hypothesized that evening binge drinking (i.e. 4-5 drink equivalent in <2hrs) would reduce sleep quality and increase morning-after blood pressure (BP) and MSNA. Following a familiarization night within the sleep laboratory, twenty-two participants (12 men, 10 women; 25±1 years) were examined after simulated binge drinking or fluid control (randomized, crossover design). Morning MSNA was successfully recorded across both conditions in 16 participants (8 men, 8 women) during a 10-minute baseline and three Valsalva's maneuvers (VM). Binge drinking reduced rapid eye movement (REM) sleep (15±1 vs. 20±1%; p=0.003), increased stage II sleep (54±1 vs. 51±1%; p=0.002), increased total urine output (2.9±0.2 vs. 2.1±0.1 liters; p<0.001), but did not alter morning-after urine specific gravity. Binge drinking increased morning-after heart rate (65 (54-72) vs. 58 (51-67) beats/min; p=0.013), but not resting BP or MSNA. Binge drinking elicited greater sympathoexcitation during VM (38±3 vs. 43±3 bursts/min, p=0.036). Binge drinking augmented heart rate (p=0.002), systolic BP (p=0.022) and diastolic (p=0.037) BP reactivity to VM phase IV, and blunted cardiovagal baroreflex sensitivity during VM phases II (p=0.028) and IV (p=0.043). In conclusion, evening binge alcohol consumption disrupted REM sleep and morning-after autonomic function. These findings provide new mechanistic insight into the potential role of binge drinking on cardiovascular risk.

中文翻译:


晚上酗酒后早晨交感神经活动



暴饮暴食会引起肌肉交感神经活动 (MSNA) 急剧而强劲的增加,但晚上暴饮对早晨 MSNA 的影响尚不清楚。本研究探讨了晚上暴饮暴食对多导睡眠和晨后 MSNA 的影响。我们假设晚上暴饮暴食(即 <2 小时内喝 4-5 杯当量)会降低睡眠质量并增加晨后血压 (BP) 和 MSNA。在睡眠实验室进行熟悉之夜后,22 名参与者(12 名男性,10 名女性;25±1 岁)在模拟酗酒或液体控制(随机、交叉设计)后接受了检查。 16 名参与者(8 名男性,8 名女性)在 10 分钟基线和 3 次 Valsalva 动作 (VM) 期间成功记录了这两种情况的早晨 MSNA。酗酒会减少快速眼动 (REM) 睡眠(15±1 vs. 20±1%;p=0.003),增加 II 期睡眠(54±1 vs. 51±1%;p=0.002),总尿量增加(2.9±0.2 vs. 2.1±0.1 升;p<0.001),但不会改变晨后尿比重。暴饮暴食会增加晨后心率(65 (54-72) 次/分钟 vs. 58 (51-67) 次/分钟;p=0.013),但不会增加静息血压或 MSNA。 VM期间暴饮暴食会引起更大的交感神经兴奋(38±3 vs. 43±3 爆发/分钟,p=0.036)。酗酒会增加心率 (p=0.002)、收缩压 (p=0.022) 和舒张压 (p=0.037) 对 VM IV 期的血压反应性,并减弱 VM II 期 (p=0.028) 和 IV (p) 期间的心血管压力反射敏感性=0.043)。总之,晚上暴饮暴食会扰乱快速眼动睡眠和晨后自主神经功能。这些发现为暴饮暴食对心血管风险的潜在作用提供了新的机制见解。
更新日期:2020-11-13
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