当前位置：
X-MOL 学术
›
Adv. Healthcare Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Engineered Microsystems for Spheroid and Organoid Studies
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-13 , DOI: 10.1002/adhm.202001284 Sung-Min Kang 1 , Daehan Kim 2 , Ji-Hoon Lee 3, 4 , Shuichi Takayama 3, 4 , Joong Yull Park 2
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-13 , DOI: 10.1002/adhm.202001284 Sung-Min Kang 1 , Daehan Kim 2 , Ji-Hoon Lee 3, 4 , Shuichi Takayama 3, 4 , Joong Yull Park 2
Affiliation
|
3D in vitro model systems such as spheroids and organoids provide an opportunity to extend the physiological understanding using recapitulated tissues that mimic physiological characteristics of in vivo microenvironments. Unlike 2D systems, 3D in vitro systems can bridge the gap between inadequate 2D cultures and the in vivo environments, providing novel insights on complex physiological mechanisms at various scales of organization, ranging from the cellular, tissue‐, to organ‐levels. To satisfy the ever‐increasing need for highly complex and sophisticated systems, many 3D in vitro models with advanced microengineering techniques have been developed to answer diverse physiological questions. This review summarizes recent advances in engineered microsystems for the development of 3D in vitro model systems. The relationship between the underlying physics behind the microengineering techniques, and their ability to recapitulate distinct 3D cellular structures and functions of diverse types of tissues and organs are highlighted and discussed in detail. A number of 3D in vitro models and their engineering principles are also introduced. Finally, current limitations are summarized, and perspectives for future directions in guiding the development of 3D in vitro model systems using microengineering techniques are provided.
中文翻译：
用于球体和类器官研究的工程微系统
3D 体外模型系统（例如球体和类器官）提供了使用模拟体内微环境生理特征的概括组织来扩展生理学理解的机会。与 2D 系统不同，3D 体外系统可以弥合不充分的 2D 培养物与体内环境之间的差距，为从细胞、组织到器官水平的各种组织规模的复杂生理机制提供新的见解。为了满足对高度复杂和精密系统不断增长的需求，人们开发了许多采用先进微工程技术的 3D 体外模型来回答不同的生理问题。本综述总结了用于开发 3D 体外模型系统的工程微系统的最新进展。重点强调并详细讨论了微工程技术背后的基础物理学及其重现不同类型组织和器官的不同 3D 细胞结构和功能的能力之间的关系。还介绍了一些3D体外模型及其工程原理。最后，总结了当前的局限性，并提供了指导使用微工程技术开发 3D 体外模型系统的未来方向的展望。
更新日期：2021-01-20
中文翻译：
用于球体和类器官研究的工程微系统
3D 体外模型系统（例如球体和类器官）提供了使用模拟体内微环境生理特征的概括组织来扩展生理学理解的机会。与 2D 系统不同，3D 体外系统可以弥合不充分的 2D 培养物与体内环境之间的差距，为从细胞、组织到器官水平的各种组织规模的复杂生理机制提供新的见解。为了满足对高度复杂和精密系统不断增长的需求，人们开发了许多采用先进微工程技术的 3D 体外模型来回答不同的生理问题。本综述总结了用于开发 3D 体外模型系统的工程微系统的最新进展。重点强调并详细讨论了微工程技术背后的基础物理学及其重现不同类型组织和器官的不同 3D 细胞结构和功能的能力之间的关系。还介绍了一些3D体外模型及其工程原理。最后，总结了当前的局限性，并提供了指导使用微工程技术开发 3D 体外模型系统的未来方向的展望。
京公网安备 11010802027423号