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Red/NIR Neutral BODIPY-Based Fluorescent Probes for Lighting Up Mitochondria
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2020-11-13 , DOI: 10.1016/j.saa.2020.119199
Jian Yang , Ran Zhang , Yue Zhao , Jiangwei Tian , Shifa Wang , Claude P. Gros , Haijun Xu

Two mitochondrial-targeted fluorescent probes, 2 and 3, based on a BODIPY scaffold and one or two piperidinyl groups were easily synthesized by Knoevenagel condensation. The biological imaging applications of the two probes 2 and 3 in live HepG2 cells reveal that these two probes display excellent mitochondrial imaging ability. Thus, these probes appear as promising tools for visualization of mitochondrial within live cells.



中文翻译:

基于红色/近红外中性BODIPY的荧光探针,用于照亮线粒体

通过Knoevenagel缩合可以轻松合成两个基于BODIPY支架的线粒体靶向荧光探针23,以及一个或两个哌啶基。两种探针23在活HepG2细胞中的生物学成像应用表明,这两种探针显示出优异的线粒体成像能力。因此,这些探针似乎是用于可视化活细胞内线粒体的有前途的工具。

更新日期:2020-11-13
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