Magnetic particle imaging (MPI) is an emerging imaging technique, which has the potential to provide the sensitivity, specificity and temporal resolution necessary for novel imaging advances in neurological applications. MPI relies on the detection of superparamagnetic iron-oxide nanoparticles, which allows for visualization and quantification of iron or iron-labeled cells throughout a subject. The combination of these qualities can be used to image many neurological conditions including cancer, inflammatory processes, vascular-related issues and could even focus on cell therapies and theranostics to treat these problems. This review will provide a basic introduction to MPI, discuss the current use of this technology to image neurological conditions, and touch on future applications including the potential for clinical translation.

磁粒子成像 (MPI) 是一种新兴的成像技术，它有可能为神经学应用中的新成像进展提供所需的灵敏度、特异性和时间分辨率。MPI 依赖于超顺磁性氧化铁纳米颗粒的检测，这允许对整个受试者中的铁或铁标记细胞进行可视化和量化。这些特性的组合可用于对许多神经系统疾病进行成像，包括癌症、炎症过程、血管相关问题，甚至可以专注于细胞疗法和治疗诊断学来治疗这些问题。这篇综述将对 MPI 进行基本介绍，讨论当前使用该技术对神经系统疾病进行成像，并探讨未来的应用，包括临床转化的潜力。