Translation regulation in the context of aged-associated inflammation and behavioral impairments is not well characterized. Aged individuals experience lower life quality due to behavioral impairments. In this study, we used young and aged transgenic mice that are unable to activate the cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E) to examine the role of protein translation control in aging, memory, depression, and anxiety. To determine how products of cap-dependent translation play a permissive role in aged-associated inflammation, we assessed levels of pro-inflammatory cytokines in various brain regions involved in the above-mentioned behaviors. We found that functional eIF4E is not necessary for age-related deficits in spatial and short-term memory but is important for depressive and anxiety-like behavior and this is correlated with pro-inflammatory cytokines in discrete brain regions. Thus, we have begun to elucidate a role for eIF4E phosphorylation in the context of aged-related behavioral impairments and chronic low-grade inflammation that may help identify novel immune modulators for therapeutic targets and decrease the burden of self-care among the geriatric population.

中文翻译：

---

帽子依赖性翻译在与年龄相关的神经免疫和情感行为变化中的作用

在与老年相关的炎症和行为障碍的背景下的翻译调节没有得到很好的表征。由于行为障碍，老年人的生活质量较低。在这项研究中，我们使用无法激活帽结合蛋白真核翻译起始因子 4E (eIF4E) 的年轻和老年转基因小鼠来检查蛋白质翻译控制在衰老、记忆、抑郁和焦虑中的作用。为了确定帽依赖性翻译产物如何在老年相关炎症中发挥许可作用，我们评估了与上述行为相关的各个大脑区域的促炎细胞因子水平。我们发现功能性 eIF4E 对于与年龄相关的空间和短期记忆缺陷不是必需的，但对于抑郁和焦虑样行为很重要，这与离散大脑区域的促炎细胞因子相关。因此，我们已经开始阐明 eIF4E 磷酸化在与老年相关的行为障碍和慢性低度炎症背景下的作用，这可能有助于确定治疗靶点的新型免疫调节剂并减轻老年人群的自我保健负担。