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The role of non-coding RNA network in atherosclerosis
Life Sciences ( IF 5.2 ) Pub Date : 2020-11-13 , DOI: 10.1016/j.lfs.2020.118756
Yuchan Yuan , Ling Xu , Zhaohong Geng , Jingjing Liu , Lijiao Zhang , Yuhang Wu , Dan He , Peng Qu

Atherosclerosis is the primary culprit of cardiovascular and cerebrovascular diseases. Also, atherogenesis and the development of atherosclerosis involve endothelial cells, monocytes/macrophages, smooth myocytes, and others. Increasingly, studies have found that non-coding RNA (ncRNA) which can regulate apoptosis, pyroptosis, autophagy, proliferation, and monocyte migration participates in atherogenesis and progress of atherosclerosis by the above. The ncRNA networks may be essential in regulating the complicated process of atherosclerosis. Accordingly, this review delves into the regulatory roles of ncRNA, which were introduced previously. The answer above is particularly crucial to explain further the regulatory mechanism of ncRNA in cardiovascular disorders. Furthermore, we discuss the possibility and related research of ncRNAs as a biomarker and therapeutic target for the prevention, diagnosis, and treatment of atherosclerosis.



中文翻译:

非编码RNA网络在动脉粥样硬化中的作用

动脉粥样硬化是心血管和脑血管疾病的主要元凶。而且,动脉粥样硬化的形成和动脉粥样硬化的发展涉及内皮细胞,单核细胞/巨噬细胞,平滑肌细胞等。越来越多的研究发现,如上所述,可以调节细胞凋亡,焦磷酸化,自噬,增殖和单核细胞迁移的非编码RNA(ncRNA)参与动脉粥样硬化的发生和动脉粥样硬化的进展。ncRNA网络可能在调节动脉粥样硬化的复杂过程中至关重要。因此,本综述探讨了先前介绍的ncRNA的调控作用。上述答案对于进一步解释ncRNA在心血管疾病中的调控机制至关重要。此外,

更新日期:2020-12-01
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