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Radiographic horizontal gaze deviation in the setting of acute PICA territory ischemia: A potential mimic of large vessel occlusion
Journal of the Neurological Sciences ( IF 3.6 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.jns.2020.117226
Nan N. Jiang , Demetrios J. Sahlas , Crystal Fong , Wei Wu , Sandra Monteiro , Ramiro Larrazabal

PURPOSE Horizontal gaze deviation (HGD) is a predictor of acute large vessel occlusion (LVO) and helps to expedite the triage of patients to CTA and endovascular-capable sites. Patients with acute cerebellar ischemia, particularly involving the PICA territory, can also exhibit HGD. MATERIALS AND METHODS We reviewed 2260 CTA stroke assessment cases between January 2016 and May 2020. Forty-six patients with CTA-proven acute PICA occlusions were identified and compared with 114 patients with acute LVO (ICA, M1, and M1/2). Both clinical and radiographic HGD were examined. The degree of radiographic HGD was measured for each patient. Site of ischemia was confirmed on subsequent MRI. RESULTS Of the 46 patients with acute PICA occlusions, 20 (43.5%) patients had radiographic (+) HGD with either ipsilateral or contralateral gaze deviation, 6 of whom (13.0%) displayed clinical HGD. Of the 114 patients with LVO (control group), 72 (63.2%) patients had radiographic (+) HGD, all ipsilateral, 49 of whom (68.0%) displayed clinical HGD. The mean degree of HGD between PICA and LVO were 30.0° vs. 22.9°, respectively, p < 0.001; AUC = 0.68. CONCLUSION Patients with acute PICA occlusion can exhibit either ipsilateral or contralateral HGD and a higher degree of HGD than LVO occlusion on NECT. In hyperacute stroke, the presence of radiographic HGD > 30° in the absence of ischemic changes in the MCA territory should prompt clinicians to closely evaluate for features of early ischemic changes in the cerebellar hemispheres that suggest acute PICA occlusion.

中文翻译:

急性 PICA 区域缺血情况下的 X 线水平凝视偏差:大血管闭塞的潜在模拟

目的 水平凝视偏差 (HGD) 是急性大血管闭塞 (LVO) 的预测指标,有助于加快将患者分流至 CTA 和血管内手术部位。患有急性小脑缺血的患者,尤其是涉及 PICA 区域的患者,也可以表现出 HGD。材料和方法 我们回顾了 2016 年 1 月至 2020 年 5 月期间的 2260 例 CTA 卒中评估病例。 确定了 46 名患有 CTA 证实的急性 PICA 闭塞的患者,并与 114 名患有急性 LVO(ICA、M1 和 M1/2)的患者进行了比较。检查了临床和放射学 HGD。测量每位患者的放射照相 HGD 程度。随后的 MRI 证实了缺血部位。结果 在 46 名急性 PICA 闭塞患者中,20 名 (43.5%) 患者的放射学 (+) HGD 伴有同侧或对侧凝视偏差,其中 6 名 (13. 0%) 显示临床 HGD。在 114 名 LVO 患者(对照组)中,72 名 (63.2%) 患者有放射学 (+) HGD,均为同侧,其中 49 名 (68.0%) 显示临床 HGD。PICA 和 LVO 之间的平均 HGD 度数分别为 30.0° 和 22.9°,p < 0.001;AUC = 0.68。结论 急性 PICA 闭塞患者在 NECT 上可表现出同侧或对侧 HGD,且 HGD 程度高于 LVO 闭塞。在超急性卒中中,在 MCA 区域没有缺血性变化的情况下,放射学 HGD > 30°的存在应促使临床医生密切评估提示急性 PICA 闭塞的小脑半球早期缺血性变化的特征。0%) 显示临床 HGD。PICA 和 LVO 之间的平均 HGD 度数分别为 30.0° 和 22.9°,p < 0.001;AUC = 0.68。结论 急性 PICA 闭塞患者在 NECT 上可表现出同侧或对侧 HGD,且 HGD 程度高于 LVO 闭塞。在超急性卒中中,在 MCA 区域没有缺血性变化的情况下,放射学 HGD > 30°的存在应促使临床医生密切评估提示急性 PICA 闭塞的小脑半球早期缺血性变化的特征。0%) 显示临床 HGD。PICA 和 LVO 之间的平均 HGD 度数分别为 30.0° 和 22.9°,p < 0.001;AUC = 0.68。结论 急性 PICA 闭塞患者在 NECT 上可表现出同侧或对侧 HGD,且 HGD 程度高于 LVO 闭塞。在超急性卒中中,在 MCA 区域没有缺血性变化的情况下,放射学 HGD > 30°的存在应促使临床医生密切评估提示急性 PICA 闭塞的小脑半球早期缺血性变化的特征。
更新日期:2021-01-01
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