BACKGROUND The spinal cord is one of the central nervous system. Spinal cord injury (SCI) will cause loss of physical function and dysfunction below the injury site, causing them to lose sensation and mobility, thereby reducing the quality of life of patients. Although regular rehabilitation management can reduce its severity, the current effective treatment methods are limited to the treatment of secondary injuries to SCI. The purpose of treatment should not only include the restoration of the histology of the lesion, but also should focus on the restoration of sensory and mobility and. The key to effective treatment is to reduce secondary injuries. RhoA inhibitor can improve the pathophysiological changes related to secondary injury and promote the recovery of activity ability, so it may become a clinical drug for the treatment of SCI. This article systematically analyzed the effects of RhoA inhibitors on the promotion of axon regeneration and the recovery of mobility and compared the therapeutic effects of different inhibitors on SCI and their effects on physical function recovery. METHODS We used a meta-analysis to systematically evaluate the effects of Rho inhibitors on SCI treatment and the recovery of body function. RESULTS 21 articles (738 animals) were identified in the literatures search. Studies were selected if they reported the therapeutic effects of RhoA/ROCK inhibitors (BA-210, EGCG, β-elemene, C3-exoenzmye, LINGO-1-Fc, Ibuprofen, SiRhoA, iRhoA + FK506, Fasudil, p21Cip1/WAF1, HA-1007, Y-27632 and C3bot154-182). We measure the functional recovery by BBB and BMS scores. The random effect model of weighted mean difference (WMD, 95% confidence interval) was used to analyze the effects. The WMD of the forest graph was 2.277; 95% CI: 1.705∼2.849, P < 0.001, suggesting that RhoA inhibitors can effectively treat SCI. In addition to EGCG, all the other agents also showed the effects on the activity recovery post-SCI (P < 0.05). CONCLUSION β-elemene, LINGO-1-Fc, Ibuprofen, SiRhoA, RhoA + FK506, Fasudil, p21Cip1/WAF1 and Y-27632 have similar effects to BA-210, they can promote axon germination and nerve fiber regeneration after thoracic spinal cord injury and reduce the formation of syringomyelia and protect white matter, thereby improving locomotor recovery. RhoA inhibitors have great potential to restore motor function and provide a new trend for the treatment of SCI.

中文翻译：

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探索 RhoA 抑制剂改善运动可恢复性脊髓损伤的潜力：系统评价和荟萃分析

背景技术脊髓是中枢神经系统之一。脊髓损伤（SCI）会导致损伤部位以下的身体功能丧失和功能障碍，使他们失去知觉和活动能力，从而降低患者的生活质量。虽然定期康复管理可以减轻其严重程度，但目前有效的治疗方法仅限于治疗 SCI 继发性损伤。治疗的目的不仅应包括病灶组织学的恢复，还应注重感觉和活动能力的恢复。有效治疗的关键是减少继发性伤害。RhoA抑制剂可改善继发性损伤相关的病理生理变化，促进活动能力的恢复，有望成为治疗SCI的临床药物。本文系统地分析了RhoA抑制剂对促进轴突再生和活动能力恢复的作用，比较了不同抑制剂对SCI的治疗作用及其对身体机能恢复的影响。方法我们使用荟萃分析来系统地评估 Rho 抑制剂对 SCI 治疗和身体功能恢复的影响。结果文献检索共检索到21篇文章（738只动物）。如果研究报告了 RhoA/ROCK 抑制剂（BA-210、EGCG、β-榄香烯、C3-exoenzmye、LINGO-1-Fc、布洛芬、SiRhoA、iRhoA + FK506、Fasudil、p21Cip1/WAF1、HA）的治疗效果，则被选中-1007、Y-27632 和 C3bot154-182）。我们通过 BBB 和 BMS 分数来衡量功能恢复。加权平均差（WMD，95% 置信区间）用于分析效果。森林图的 WMD 为 2.277；95% CI：1.705∼2.849，P < 0.001，表明RhoA抑制剂可以有效治疗SCI。除 EGCG 外，所有其他药物也显示出对 SCI 后活动恢复的影响（P < 0.05）。结论 β-榄香烯、LINGO-1-Fc、布洛芬、SiRhoA、RhoA+FK506、法舒地尔、p21Cip1/WAF1、Y-27632与BA-210作用相似，可促进胸脊髓损伤后轴突萌发和神经纤维再生减少脊髓空洞症的形成，保护白质，从而提高运动恢复。RhoA抑制剂具有恢复运动功能的巨大潜力，为SCI的治疗提供了新的趋势。表明 RhoA 抑制剂可以有效治疗 SCI。除 EGCG 外，所有其他药物也显示出对 SCI 后活动恢复的影响（P < 0.05）。结论 β-榄香烯、LINGO-1-Fc、布洛芬、SiRhoA、RhoA+FK506、法舒地尔、p21Cip1/WAF1、Y-27632与BA-210作用相似，可促进胸脊髓损伤后轴突萌发和神经纤维再生减少脊髓空洞症的形成，保护白质，从而提高运动恢复。RhoA抑制剂具有恢复运动功能的巨大潜力，为SCI的治疗提供了新的趋势。表明 RhoA 抑制剂可以有效治疗 SCI。除 EGCG 外，所有其他药物也显示出对 SCI 后活动恢复的影响（P < 0.05）。结论 β-榄香烯、LINGO-1-Fc、布洛芬、SiRhoA、RhoA+FK506、法舒地尔、p21Cip1/WAF1、Y-27632与BA-210作用相似，可促进胸脊髓损伤后轴突萌发和神经纤维再生减少脊髓空洞症的形成，保护白质，从而提高运动恢复。RhoA抑制剂具有恢复运动功能的巨大潜力，为SCI的治疗提供了新的趋势。p21Cip1/WAF1和Y-27632与BA-210的作用相似，可促进胸脊髓损伤后轴突萌发和神经纤维再生，减少脊髓空洞症的形成，保护白质，从而促进运动恢复。RhoA抑制剂具有恢复运动功能的巨大潜力，为SCI的治疗提供了新的趋势。p21Cip1/WAF1和Y-27632与BA-210的作用相似，可促进胸脊髓损伤后轴突萌发和神经纤维再生，减少脊髓空洞症的形成，保护白质，从而促进运动恢复。RhoA抑制剂具有恢复运动功能的巨大潜力，为SCI的治疗提供了新的趋势。