Genetic and environmental factors are thought to influence the activity of systemic lupus erythematosus (SLE), but relatively little is known about the effects of ambient air pollution. Using pollution data from air monitoring stations in the urban centers in Santiago Chile, along with daily patient hospitalization data from 2001 to 2012, an association between ambient air pollution and daily hospital admissions for SLE was tested using generalized linear models. Averaged over all regions pollutant mean 24 hour concentrations were: 0.96 ppm carbon monoxide (CO), 64 ppb ozone (O₃), 43 ppb nitrogen dioxide (NO₂), 9 ppb sulphur dioxide (SO₂), 29μg/m³ particulate matter ≤ 2.5 μm in mean aerodynamic diameter (PM_2.5), and 67μg/m³ particulate matter ≤ 10 μm in diameter (PM₁₀). The relative risk estimates in single pollutant models for an interquartile range (IQR) increase in pollutant were: RR=1.34 (95% CI: 1.06-1.83) for SO₂, RR=1.60 (95% CI: 1.15-2.24) for CO, and RR=1.41 (95% CI: 1.14-1.86) for PM_2.5. In two-pollutant models, the significance of SO₂ and PM_2.5 persisted despite adjustments for each of the other measured pollutants. These findings suggest that acute increases in air pollution increase the risk of hospitalization with a primary diagnosis of SLE.

人们认为遗传因素和环境因素会影响系统性红斑狼疮（SLE）的活动，但对环境空气污染的影响知之甚少。利用智利圣地亚哥市区中心空气监测站的污染数据以及2001年至2012年的每日患者住院数据，使用广义线性模型测试了环境空气污染与SLE的每日住院人数之间的关联。所有区域的平均污染物平均24小时浓度为：0.96 ppm一氧化碳（CO），64 ppb臭氧（O ₃），43 ppb二氧化氮（NO ₂），9 ppb二氧化硫（SO ₂），29μg/ m ³颗粒平均空气动力学直径≤2.5μm的物质（PM _2.5），直径67μg/ m ^3的颗粒物≤10μm（PM ₁₀）。污染物四分位数间距（IQR）增加的单一污染物模型的相对风险估计为：SO ₂ RR = 1.34 （95％CI：1.06-1.83），CO RR = 1.60（95％CI：1.15-2.24） ，对于PM _2.5，RR = 1.41（95％CI：1.14-1.86）。在两种污染物的模型中，尽管对其他每种污染物进行了调整，SO ₂和PM _2.5的重要性仍然存在。这些发现表明，空气污染的急剧增加会增加对SLE的初步诊断的住院风险。