An efficient approach for the synthesis of hard-to-reach 3,4-disubstituted thiophene derivatives: 4,5,9,10-tetrahydrothieno[3',4;5,6]-cycloocta[1,2-c]thiophene, 1H,4H-thieno[3,4-d][1,2]dioxine, 4-(hydroxymethyl)thiophene-3-carbaldehyde, based on consecutive transformations of bis(2-chloropropenyl) sulfide has been found. Transformations were realized without isolation of the intermediate compounds. The reactivity of 4,5,9,10-tetrahydrothieno[3',4;5,6]cycloocta[1,2-c]thiophene has been studied based on the example of acetylation reaction, and the possibility of obtaining bifunctional derivatives with the participation of both thiophene rings has been shown. The structure of some synthesized compounds has been studied with X-ray diffraction method.

合成难以达到的3,4-二取代噻吩衍生物的有效方法：4,5,9,10-四氢噻吩并[3'，4; 5,6]-环辛基[1,2- c ]噻吩基于双（2-氯丙烯基）硫化物的连续转化，发现了1 H，4 H-噻吩并[3,4- d ] [1,2]二恶英，4-（羟甲基）噻吩-3-甲醛。无需分离中间体化合物即可实现转化。4,5,9,10-四氢噻吩并[3'，4; 5,6]环辛基[1,2- c已经基于乙酰化反应的实例研究了噻吩，并且已经显示了获得两个噻吩环参与的双官能衍生物的可能性。用X射线衍射方法研究了一些合成化合物的结构。