Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism and remains to be characterized. In this study, we show that Disco-interacting protein 2a null mice do not exhibit overt phenotype defects. However, the body composition differences were observed in these mice under different dietary regimens. The neutral lipid composition of two different diets was characterized, and it was observed that the new-born mice grow relatively slower than the wild-type mice with delayed appearance of features such as dentition when fed with high-triacylglycerol NIN-formulation diet. The high-diacylglycerol Safe-formulation diet was found to accumulate more fat mass in mice than those fed with high-triacylglycerol NIN-formulation diet beyond 10 months. These findings point to a proposed relationship between dietary components (particularly the lipid composition) and body composition along with the growth of neonates in mice lacking the gene Disco-interacting protein 2a.

Disco-interacting protein 2 是一种高度保守的三域蛋白质，具有两个串联的腺苷酸形成域。建议通过影响脂质代谢来影响参与神经元发育的过程，但仍有待表征。在这项研究中，我们表明 Disco 相互作用蛋白 2a 无效小鼠不表现出明显的表型缺陷。然而，在不同饮食方案下的这些小鼠中观察到身体成分差异。对两种不同饮食的中性脂质成分进行了表征，观察到新生小鼠在喂食高三酰甘油 NIN 配方饮食时比野生型小鼠生长相对较慢，具有延迟出现牙列等特征。研究发现，在 10 个月后，高甘油二酯安全配方饮食在小鼠体内积累的脂肪量比高甘油三酯 NIN 配方饮食的小鼠要多。这些发现表明，在缺乏 Disco 相互作用蛋白 2a 基因的小鼠中，膳食成分（尤其是脂质成分）和身体成分以及新生儿的生长之间存在一种拟议的关系。