Hypoxia is a hallmark of solid tumors, and it significantly impairs the overall anticancer efficacy, particularly photodynamic therapy (PDT). Herein, a catalase-like nanovesicle with near-infrared light-responsiveness, that is, platinum/gold nanoshell encapsulated chlorin e6 (Ce6)/resveratrol (Res) liposome (Pt@Au-Ce6/Res-Lip), was developed to surmount this intractable issue. The Pt@Au-Ce6/Res-Lip can decompose overexpressed H₂O₂ in tumor microenvironment to produce vast amounts of O₂ for further enhancement of the PDT. Under the 808 nm laser irradiation, the Au nanoshells induced hyperthermia at the lesion site to ablate tumor cells, simultaneously inducing the controlled release of photosensitizer Ce6 and chemotherapeutic agent Res. Moreover, stimulated by 660 nm laser, numerous reactive oxygen species were formed to induce apoptosis and necrosis of tumor cells. With the cascade of trimodal therapeutic modality options (chemotherapy, photothermal therapy, and PDT), the Pt@Au-Ce6/Res-Lip showed ultrahigh tumor inhabitation rate in in vitro and in vivo studies, signifying that the Pt@Au-Ce6/Res-Lip nanovesicle is a promising candidate for effective cancer therapy.

缺氧是实体瘤的标志，它严重损害了整体抗癌功效，特别是光动力疗法（PDT）。在这里，开发了具有近红外光响应性的过氧化氢酶样纳米囊泡，即铂/金纳米壳包裹的二氢卟酚e6（Ce6）/白藜芦醇（Res）脂质体（Pt @ Au-Ce6 / Res-Lip）。这个棘手的问题。Pt @ Au-Ce6 / Res-Lip可以分解肿瘤微环境中过表达的H ₂ O ₂，从而产生大量的O ₂用于进一步增强PDT。在808 nm激光照射下，Au纳米壳在病灶部位引起热疗，从而消融肿瘤细胞，同时诱导了光敏剂Ce6和化学治疗剂Res的受控释放。此外，在660 nm激光的刺激下，形成了许多活性氧，以诱导肿瘤细胞的凋亡和坏死。随着三峰治疗模式选择（化学疗法，光热疗法和PDT）的级联，Pt @ Au-Ce6 / Res-Lip在体外和体内研究中均显示出超高的肿瘤栖息率，这表明Pt @ Au-Ce6 / Res-Lip纳米囊泡是有效癌症治疗的有希望的候选者。