Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic nuclear polarization at low temperature and moderate magnetic field, followed by an instantaneous melting and dilution of the sample happening inside the polarizer. Although the technique is well established and the outstanding signal enhancement paved the way towards many applications precluded to conventional NMR, the race to develop new methods allowing higher throughput, faster and higher polarization, and longer exploitation of the signal is still vivid. In this work, we review the most recent advances on dissolution-DNP methods trying to overcome the original technique’s shortcomings. The review describes some of the new approaches in the field, first, in terms of sample formulation and properties, and second, in terms of instrumentation.

Dissolution-DNP 是一种将液态 NMR 灵敏度提高几个数量级的方法。该技术包括在低温和中等磁场下通过固态动态核极化使样品超极化，然后在极化器内部发生样品的瞬时熔化和稀释。尽管该技术已经成熟，而且出色的信号增强为许多传统 NMR 所排除的应用铺平了道路，但开发新方法的竞赛仍然很激烈，该方法允许更高的吞吐量、更快和更高的极化以及更长时间的信号利用。在这项工作中，我们回顾了溶解-DNP 方法的最新进展，试图克服原始技术的缺点。该评论描述了该领域的一些新方法，首先，