Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core–shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes.

Graphic abstract

中文翻译：

---

机械强度大的纤维素纳米晶与羟基磷灰石的生物相容性复合材料

考虑到复合材料在生物组织中的广泛应用，探索简单的制备工艺来制备用于生物组织的CNC @ HAp仍然是一个具有挑战性的课题。在这项工作中，旨在通过简单且环保的工艺和材料制造CNC @ HAp复合材料，我们建议在悬浮液中存在CNC的情况下进行中和滴定。通过简单的水中和滴定法成功合成了纤维素纳米晶体（CNC）和羟基磷灰石（HAp）（CNC @ HAp）的核-壳结构复合材料。研究的方法成功地将CNC控制器与一定量的HAps杂交，并易于将HAps的涂覆量控制在9 wt％至17 wt％之间。尤其是，CNC @ HAp球团很容易通过简单的压缩成型法从混合的CNCs和HAps的粉末中制备而成，这些球团显示出超过500 N的高机械强度和小于5％的低应变。研究的过程和产品都是环保的，无毒，简单而纯净的，因此CNC @ HAp可以很容易地应用于组织工程和医学目的。

图形摘要