MicroRNAs (miRNAs) are a class of small non-coding RNAs that have emerged as potential predictive, prognostic, and therapeutic biomarkers, relevant to many pathophysiological conditions including limb immobilization, osteoarthritis, sarcopenia, and cachexia. Impaired musculoskeletal homeostasis leads to distinct muscle atrophies. Understanding miRNA involvement in the molecular mechanisms underpinning conditions such as muscle wasting may be critical to developing new strategies to improve patient management. MicroRNAs are powerful post-transcriptional regulators of gene expression in muscle and, importantly, are also detectable in the circulation. MicroRNAs are established modulators of muscle satellite stem cell activation, proliferation, and differentiation, however, there have been limited human studies that investigate miRNAs in muscle wasting. This narrative review summarizes the current knowledge as to the role of miRNAs in the skeletal muscle differentiation and atrophy, synthesizing the findings of published data. Cite this article: Bone Joint Res 2020;9(11):798-807.

中文翻译：

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microRNA 在肌肉再生以及与萎缩、恶病质、骨质疏松症和骨关节炎等肌肉功能障碍相关的疾病中的作用。


MicroRNA (miRNA) 是一类小型非编码 RNA，已成为潜在的预测、预后和治疗生物标志物，与许多病理生理状况相关，包括肢体固定、骨关节炎、肌肉减少症和恶病质。肌肉骨骼稳态受损会导致明显的肌肉萎缩。了解 miRNA 参与肌肉萎缩等疾病的分子机制可能对于制定改善患者管理的新策略至关重要。 MicroRNA 是肌肉中基因表达的强大转录后调节因子，重要的是，它也可以在循环中检测到。 MicroRNA 是肌肉卫星干细胞激活、增殖和分化的既定调节剂，然而，研究 miRNA 在肌肉萎缩中的人类研究还很有限。这篇叙述性综述总结了当前关于 miRNA 在骨骼肌分化和萎缩中的作用的知识，综合了已发表的数据的发现。引用本文：骨关节研究2020;9(11):798-807。