With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.

中文翻译：

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基于干细胞的男性生殖力疗法：现状和未来前景。

近年来，随着男性生育力的下降，保存男性生育力的策略受到越来越多的关注。在这项研究中，通过回顾当前的治疗方法和最新出版物，我们描述了基于干细胞的男性生殖力保存疗法的研究进展和未来方向，重点是精原干细胞（SSC），SSC壁,、基于SSC的使用睾丸类器官，其他干细胞类型，例如间充质干细胞和干细胞衍生的细胞外囊泡。总之，对生殖细胞微环境，干细胞来源的细胞外囊泡和睾丸类器官的更全面的了解将在保持男性生育力中发挥重要作用。