Mesenchymal stem cells (MSC) modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models. Human MSC derived from adipose tissue (haMSC) differentiate into cells with pacemaker properties in vitro, but little is known about their behavior after intracardiac transplantation.

中文翻译：

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从脂肪组织移植到猪心脏中的分化人类间充质干细胞的体内心脏起搏器功能。

实验动物模型显示，经基因转移修饰的间充质干细胞（MSC）可表达心脏起搏器通道，例如HCN2或HCN4，可在心脏内移植后引发起搏器功能。源自脂肪组织（haMSC）的人类MSC在体外分化为具有起搏器特性的细胞，但对于心脏内移植后它们的行为知之甚少。