Adipose-derived mesenchymal stem cells (ASCs) are characterized by long-term self-renewal and a high proliferation rate. Under adequate conditions, they may differentiate into cells belonging to mesodermal, endodermal or ectodermal lineages. Pericytes support endothelial cells and play an important role in stabilizing the vessel wall at the microcirculation level. The loss of pericytes, as occurs in diabetic retinopathy, results in a breakdown of the blood-retina barrier (BRB) and infiltration of inflammatory cells. In this context, the use of pericyte-like differentiated ASCs may represent a valuable therapeutic strategy for restoring BRB damage.

中文翻译：

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人脂肪来源的间充质干细胞的周细胞样分化：一项体外研究。

脂肪来源的间充质干细胞（ASC）具有长期自我更新和高增殖率的特点。在适当条件下，它们可能分化为属于中胚层，内胚层或外胚层谱系的细胞。周细胞支持内皮细胞，并在微循环水平稳定血管壁中起重要作用。如在糖尿病性视网膜病中发生的周细胞的损失导致血-视网膜屏障（BRB）的破坏和炎性细胞的浸润。在这种情况下，使用周细胞样分化的ASCs可能代表恢复BRB损伤的有价值的治疗策略。