An effective protocol for the synthesis of guaiazulene substituted furan derivatives via three-component reactions of guaiazulene, α-ketoaldehyde, and 1,3-dicarbonyl compound under mild conditions in good yield is reported. All of these compounds were evaluated for their antioxidant properties in vitro against lipid peroxidation and several compounds were found to have good activities.

中文翻译：

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（Guaiazulen-1-yl）呋喃的合成和评估抗氧化活性的简单途径

报道了在温和的条件下以良好的产率通过愈创木酚，α-酮醛和1,3-二羰基化合物的三组分反应合成愈创木酚烯取代的呋喃衍生物的有效方案。评价了所有这些化合物的体外抗脂质过氧化的抗氧化性能，发现几种化合物具有良好的活性。