A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent,Organic & Biomolecular Chemistry

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A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-06 , DOI: 10.1039/d0ob01966f
Silvia Anselmi ₁ , Siyu Liu , Seong-Heun Kim , Sarah M Barry , Thomas S Moody , Daniele Castagnolo

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A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

中文翻译：

利用 AcOEt 作为溶剂和试剂的双重作用，一种温和且化学选择性的 CALB 生物催化合成亚砜

已经开发了一种温和、化学选择性和可持续的亚砜生物催化合成，利用 CALB 和使用 AcOEt，具有更环保的反应溶剂和酶底物的双重作用。一系列亚砜，包括药物奥美拉唑，已经以高产率和优异的E因子合成。

更新日期：2020-11-12

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